两个新的黄烷酮从Polytrichum公社Hedw。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-02-01 DOI:10.1080/14786419.2023.2272030

Hao Cheng , Yan-Lei Su , Meng-Tong Liu , Shi-Nong Yuan , Shao-Nan Wang , Fang-Jie Hou , Ma Dong-Lai , Duan Xu-Hong

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引用次数: 0

摘要

从Polytrichum community Hedw中分离到7种黄烷酮，包括两种与苯乙烯单元偶联的新化合物，公报子C（1）和D（2），以及5种已知化合物。使用广泛的光谱分析确定了所有化合物的平面结构。通过比较实验ECD和计算ECD，确定了两种新化合物的绝对构型。评价了所有分离株对HCT-116、BGC803、MCF7和PANC-1细胞系的细胞毒性。Communin D对BGC803细胞表现出显著的细胞毒性活性，IC50值为9.3 μM。

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Two new flavanones from Polytrichum commune Hedw

Seven flavanones, including two new compounds coupled with styryl units, communins C (1) and D (2), as well as five known compounds, were isolated from Polytrichum commune Hedw. The planar structures of all compounds were determined using extensive spectroscopic analysis. The absolute configurations of two new compounds were assigned by comparing experimental ECD with calculated ECD. The cytotoxicity of all isolates against HCT-116, BGC803, MCF7 and PANC-1 cell lines was evaluated. Communin D exhibited significant cytotoxic activity on BGC803 cells with an IC₅₀ value of 9.3 μM.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.