Functionalization of C,C-palladacycles: application in the synthesis of functional molecules

Significant advancements have been achieved in the field of C,C-palladacycles functionalization in recent decades, which have greatly contributed to the synthesis of intricate drug molecules, natural products, innovative materials, and chiral ligands. Additionally, these advancements have led to the establishment of highly efficient and atom-economic synthetic processes. Based on the differences in the C–Pd bonds, C, C-palladacycles can be further classified into several main types: C(aryl), C(alkyl)-, C(aryl), C(aryl)-, C(aryl), C(vinyl)-, and C(alkyl), C(carbonyl)-palladacycles. This minireview will highlight the recent advances in the synthesis of functional molecules through the functionalization of different C,C-palladacycles, and we hope this survey will inspire future strategic developments for C,C-palladacycle catalysts and their synthetic application.