非肌肉性和肌肉性尿路上皮癌症中PD-L1表达的定量免疫荧光评价

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY

Moscow University Chemistry Bulletin Pub Date : 2023-10-13 DOI:10.3103/S0027131423060032

T. A. Bogush, K. S. Spiridonova, E. A. Bogush, A. N. Grishanina, A. M. Scherbakov, M. I. Volkova, Z. M. Safarov, V. B. Matveev, V. S. Kosorukov

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引用次数: 0

摘要

在56个癌症尿路上皮癌（BC）样品中对PD-L1蛋白的表达进行定量。在所有BC样本中检测到PD-L1表达，而在非肌肉浸润性膀胱癌症（NMIBC）中，这一得分是癌症（MIBC）的1.5倍（p=0.001）。在20%的MIBC样本和68%的NMIBC肿瘤中观察到高PD-L1表达水平（≥30%），即。，3.4倍（p=0.0004）。最后一个事实证明了在NMIBC发病时开始使用免疫检查点抑制剂治疗的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Quantitative Immunofluorescence Evaluation of PD-L1 Expression in Non-Muscle-Invasive and Muscle-Invasive Urothelial Bladder Cancer

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Quantitative Immunofluorescence Evaluation of PD-L1 Expression in Non-Muscle-Invasive and Muscle-Invasive Urothelial Bladder Cancer

The expression of PD-L1 protein is quantified in 56 samples of urothelial bladder cancer (BC). PD-L1 expression is detected in all BC samples, while in non-muscle-invasive bladder cancer (NMIBC) this score is 1.5 times higher than in muscle-invasive bladder cancer (MIBC) (p = 0.001). High PD-L1 expression level (≥30%) is observed in 20% of MIBC samples and among NMIBC tumors in 68% of cases, i.e., 3.4 times more often (p = 0.0004). The last fact justifies the prospect of starting therapy with immune checkpoint inhibitors at the onset of the disease for NMIBC.

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来源期刊

Moscow University Chemistry Bulletin CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.30

自引率

14.30%

发文量

期刊介绍： Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.