解读纳米药物在卵巢癌症治疗中的应用:综述。

Pooja Mathur, Shailendra Bhatt, Suresh Kumar, Sweta Kamboj, Rohit Kamboj, Arpana Rana, Harish Kumar, Ravinder Verma
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摘要

大多数折磨女性生殖系统的致命癌症发生在卵巢。全球每年约有1.4万名女性死于卵巢癌症,这使其成为美国女性中第六常见的癌症相关死亡。现代尖端的治疗方法,如化疗和手术,经常会产生完全缓解,但复发率仍然很高。当这种致残性疾病被诊断出来时,通常很少有治疗选择,因为它表现得很安静。医疗保健从业人员必须从根本上掌握癌症的警告信号和症状,以及可用的成像技术和治疗选择,为患者提供尽可能好的治疗。近年来,医学纳米技术学科在解决问题和加强包括癌症在内的各种疾病的检测和治疗方面取得了很大进展。本文就癌症的类型、危险因素及治疗方法作一综述。我们随后讨论了卵巢癌症的病理生理学和危险因素。这篇综述还强调了卵巢癌症中涉及的各种信号通路。我们对纳米领域基础研究的最新发现进行了全面整合,揭示了人们对这些纳米药物在卵巢癌症治疗中的强烈兴趣。然而,正如正在进行的临床试验数量相对较少所表明的那样,这些纳米药物仍然需要更多的研究。本文将为癌症的治疗提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Deciphering the Therapeutic Applications of Nanomedicine in Ovarian Cancer Therapy: An Overview.

The majority of deadly cancers that afflict the female reproductive system occur in the ovary. Around 1,40,000 women worldwide die from ovarian cancer each year, making it the sixth most common cancer-associated deceases among females in the United States. Modern, cutting-edge treatments like chemotherapy and surgery frequently produce full remissions, but the recurrence rate is still very high. When this crippling condition is diagnosed, there are frequently few therapeutic choices available because of how quietly it manifests. Healthcare practitioners must have a fundamental grasp of the warning signs and symptoms of ovarian cancer, as well as the imaging techniques and treatment choices available, to give the patient the best care possible. The discipline of medical nanotechnology has gained a lot of momentum in recent years in resolving issues and enhancing the detection and treatment of different illnesses, including cancer. This article gives a brief summary of types, risk factors and approaches to ovarian cancer treatment. We subsequently discussed the pathophysiology of ovarian cancer with the risk factors. This review also emphasizes the various signalling pathways involved in ovarian cancer. Our comprehensive integration of recent findings in fundamental research in the nano arena reveals the strong interest in these nanomedicines in ovarian cancer treatment. However, these nanomedicines still require more research, as indicated by the comparatively small number of clinical trials ongoing. This article will provide a reference for ovarian cancer treatment.

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