胃轻瘫的药物治疗：什么（仍然）在地平线上？

IF 4 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2023-10-01 DOI:10.1016/j.coph.2023.102395

D. Schweckendiek, D. Pohl

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引用次数: 0

摘要

胃轻瘫是上消化道的一种神经肌肉疾病。患者通常会抱怨早期饱腹、餐后饱腹、恶心和呕吐。病因是多因素的。治疗策略包括营养支持、药物或手术治疗难治性病例。甲氧氯普胺是美国食品药品监督管理局批准的第一种也是唯一一种治疗（糖尿病）胃轻瘫的药物。一些化合物目前正在进行临床试验。然而，一些希望的灯塔最近失败了。在这里，我们介绍了未来可能的治疗方案的最新情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pharmacologic treatment of gastroparesis: What is (still) on the horizon?

Gastroparesis is a neuromuscular disorder of the upper gastrointestinal tract. Patients typically complain about early satiety, postprandial fullness, nausea and vomiting. Etiology is multifactorial. Treatment strategies include nutritional support, pharmacologic agents or surgery for refractory cases. Metoclopramide is the first and only FDA approved pharmacologic agent for (diabetic) Gastroparesis. A couple of compounds are currently in clinical testing. Some beacons of hope have failed recently, however. Here we present an update on possible future treatment options.

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.