单细胞和空间转录组学在癌症细胞-细胞相互作用分析中的应用前景。

IF 12.1 1区医学 Q1 ONCOLOGY

Seminars in cancer biology Pub Date : 2023-10-01 DOI:10.1016/j.semcancer.2023.07.001

Xinyi Wang , Axel A. Almet , Qing Nie

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引用次数: 2

摘要

细胞与细胞的相互作用指导细胞的命运和功能。这些相互作用被劫持以促进癌症的发展。单细胞转录组学和空间转录组学已成为研究人员在无与伦比的遗传深度上描述癌症转录景观的强大新工具。在这篇综述中，我们讨论了从非空间单细胞RNA测序推断细胞-细胞相互作用的快速增长的计算工具阵列，以及空间转录组学数据的有限但不断增长的方法。重点介绍了这些计算工具的下游分析及其在癌症研究中的应用。最后，我们提出了进一步扩展的几个方向，预计多组学癌症数据的可用性会增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The promising application of cell-cell interaction analysis in cancer from single-cell and spatial transcriptomics

Cell-cell interactions instruct cell fate and function. These interactions are hijacked to promote cancer development. Single-cell transcriptomics and spatial transcriptomics have become powerful new tools for researchers to profile the transcriptional landscape of cancer at unparalleled genetic depth. In this review, we discuss the rapidly growing array of computational tools to infer cell-cell interactions from non-spatial single-cell RNA-sequencing and the limited but growing number of methods for spatial transcriptomics data. Downstream analyses of these computational tools and applications to cancer studies are highlighted. We finish by suggesting several directions for further extensions that anticipate the increasing availability of multi-omics cancer data.

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来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.