[新的和已建立的晚期癌症多模式治疗策略]。

Q4 Medicine
Praxis Pub Date : 2023-09-01
Daniel C Steinemann, Beat P Müller-Stich, Fiorenzo Angehrn, Fabio Nocera
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引用次数: 0

摘要

简介:局部晚期癌症局部复发的风险很高,可以通过多模式治疗来降低。已经建立了新辅助放射治疗或放化疗。然而,这并没有证明能提高整体生存率。新辅助放疗或放化疗后辅助化疗的益处尚不清楚。目前的研究正在研究在直肠切除术后进行不同顺序的放疗和化疗的全新辅助治疗。该手术显示高达28%的病理学完全缓解,以及无病和无转移生存率的提高。在研究条件下,在临床完全缓解的情况下,只有在局部肿瘤复发的情况下才能考虑密切随访和手术的密切等待。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[New and Established Multimodal Therapeutic Strategies in Advanced Rectal Cancer].

Introduction: Locally advanced rectal cancer has a high risk of local recurrence which can be reduced by multimodal therapy. Neoadjuvant radiotherapy or radiochemotherapy has been established. Nevertheless, this has not proved to improve overall survival. The benefit of adjuvant chemotherapy after neoadjuvant radiotherapy or radiochemotherapy remains unclear. Current studies are investigating total neoadjuvant therapy with different sequences of radiotherapy and chemotherapy followed by rectal resection. This procedure shows high pathologic complete remissions up to 28 % as well as an improvement in disease-free and metastasis-free survival. Under study conditions, in case of clinical complete remission, watchful waiting with close follow-up and surgery can be considered only in case of local tumor recurrence.

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来源期刊
Praxis
Praxis Medicine-Medicine (all)
CiteScore
0.40
自引率
0.00%
发文量
146
审稿时长
12 weeks
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