影响大脑功能的表观遗传学修饰：身体活动、微量营养素、咖啡因、毒素和成瘾物质的影响。

IF 4.4 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemistry international Pub Date : 2023-10-11 DOI:10.1016/j.neuint.2023.105627

Rahul Mallick , Asim K. Duttaroy

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引用次数: 0

摘要

基因表达的变化与许多大脑功能有关。表观遗传学过程通过组蛋白修饰和DNA甲基化或RNA介导的过程调节基因表达，这对大脑功能很重要。因此，表观遗传学变化也是大脑疾病的一部分，如精神疾病和成瘾。了解不同因素对大脑表观基因组的作用可能有助于我们理解大脑的功能。这篇综述讨论了咖啡因、脂质、成瘾物质、体育活动和污染物对大脑表观遗传学变化的影响及其对大脑功能的调节作用。

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Epigenetic modification impacting brain functions: Effects of physical activity, micronutrients, caffeine, toxins, and addictive substances

Changes in gene expression are involved in many brain functions. Epigenetic processes modulate gene expression by histone modification and DNA methylation or RNA-mediated processes, which is important for brain function. Consequently, epigenetic changes are also a part of brain diseases such as mental illness and addiction. Understanding the role of different factors on the brain epigenome may help us understand the function of the brain. This review discussed the effects of caffeine, lipids, addictive substances, physical activity, and pollutants on the epigenetic changes in the brain and their modulatory effects on brain function.

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来源期刊

Neurochemistry international 医学-神经科学

CiteScore

8.40

自引率

2.40%

发文量

128

审稿时长

37 days

期刊介绍： Neurochemistry International is devoted to the rapid publication of outstanding original articles and timely reviews in neurochemistry. Manuscripts on a broad range of topics will be considered, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of CNS function, neuroimmunology, metabolism as well as the neurochemistry of neurological and psychiatric disorders of the CNS.