间充质干细胞对伤口感染的影响。

Mansoor Khaledi, Bita Zandi, Zeinab Mohsenipour
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摘要

伤口感染通常需要长时间的护理和繁重的治疗过程。此外,丰富的环境使伤口成为微生物生长的理想场所。稳定的结构,如生物膜和耐药菌株,会导致愈合过程的延迟,这已成为伤口治疗的重要挑战之一。许多研究都集中在处理伤口感染的替代方法上。间充质基质细胞(MSCs)是一种新的、极具潜力的方法。MSCs是中胚层衍生的多能干成体细胞,具有自我更新、多向分化和免疫控制的能力。此外,间充质干细胞具有抗炎和抗凋亡作用。理学硕士作为多能干基质细胞,分化为许多成熟细胞。此外,MSC产生抗微生物化合物,如抗微生物肽(AMP),并分泌免疫调节剂,这是伤口愈合中考虑的两个基本特征。尽管有这些优点,但保留MSCs的结构和活性被认为是治疗中最重要的一点。MSCs对参与伤口感染的微生物的抗菌作用已在各种研究中得到证实。在这篇综述中,我们旨在讨论MSCs在感染伤口愈合过程中的抗菌和治疗应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of Mesenchymal Stem Cells on the Wound Infection.

Wound infection often requires a long period of care and an onerous treatment process. Also, the rich environment makes the wound an ideal niche for microbial growth. Stable structures, like biofilm, and drug-resistant strains cause a delay in the healing process, which has become one of the important challenges in wound treatment. Many studies have focused on alternative methods to deal the wound infections. One of the novel and highly potential ways is mesenchymal stromal cells (MSCs). MSCs are mesoderm-derived pluripotent adult stem cells with the capacity for self-renewal, multidirectional differentiation, and immunological control. Also, MSCs have anti-inflammatory and antiapoptotic effects. MScs, as pluripotent stromal cells, differentiate into many mature cells. Also, MSCs produce antimicrobial compounds, such as antimicrobial peptides (AMP), as well as secrete immune modulators, which are two basic features considered in wound healing. Despite the advantages, preserving the structure and activity of MSCs is considered one of the most important points in the treatment. MSCs' antimicrobial effects on microorganisms involved in wound infection have been confirmed in various studies. In this review, we aimed to discuss the antimicrobial and therapeutic applications of MSCs in the infected wound healing processes.

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