手术切除联合硼替佐米、环磷酰胺和地塞米松成功治疗硬膜外髓外浆细胞瘤。

Current health sciences journal Pub Date : 2023-04-01 Epub Date: 2023-06-30 DOI:10.12865/CHSJ.49.02.288
Artur Eduardo Martio, Guilherme José Miotto, Paulo Moacir Mesquita Filho, William Scheffer Chaves, Octávio Ruschel Karam
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引用次数: 0

摘要

浆细胞肿瘤很常见,占所有恶性肿瘤的1%以上。其最常见的形式是多发性骨髓瘤,但也存在其他形式,如髓外浆细胞瘤(EMP)。继发于这些病变的脊髓压迫并不罕见,然而,通常存在邻近骨骼受累。孤立硬膜外EMP引起的脊髓压迫极为罕见,迄今为止只有一例报告。我们描述了一例75岁的女性患者,由于孤立的硬膜外EMP与轻链淀粉样变性相关,出现轻瘫。她接受了手术减压和新辅助化疗,目前有15个月的无病期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Epidural Extramedullary Plasmacytoma Successfully Treated with Surgical Excision and Bortezomib, Cyclophosphamide and Dexamethasone.

Epidural Extramedullary Plasmacytoma Successfully Treated with Surgical Excision and Bortezomib, Cyclophosphamide and Dexamethasone.

Epidural Extramedullary Plasmacytoma Successfully Treated with Surgical Excision and Bortezomib, Cyclophosphamide and Dexamethasone.

Epidural Extramedullary Plasmacytoma Successfully Treated with Surgical Excision and Bortezomib, Cyclophosphamide and Dexamethasone.

Plasma cell neoplasms are common, accounting for more than 1% of all malignancies. Its most common form is multiple myeloma, but others, such as extramedullary plasmacytoma (EMP), exist. Spinal cord compression secondary to these pathologies is not uncommon, however, adjacent bone involvement is usually present. Spinal cord compression caused by isolated epidural EMP is extremely rare, with only one case reported to date. We describe the case of a 75-year-old female patient that presented with paraparesis, due to an isolated epidural EMP associated with light chain amyloidosis. She was treated with surgical decompression and neoadjuvant chemotherapy, and is currently with a 15-month disease-free period.

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