含硼化合物在阿尔茨海默病中的裂解潜力。

Marvin Antonio Soriano-Ursúa, Eunice Dalet Farfán-García
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引用次数: 0

摘要

阿尔茨海默病(AD)是世界范围内一种相关的神经退行性疾病。其相关性主要是由于其高流行率和高全球负担。类金属化合物引起了人们的关注,因为它们的血清水平在受影响的患者和健康人之间似乎有所不同。另一方面,一些类金属的原子已被包含在生物活性分子中,发挥了一些有趣的作用,主要是由于它们对神经退行性变的改善作用。从这个意义上说,含硼化合物(BCC)已被探索用于调节或预防神经退行性变。例如,据报道,硼酸是一种具有抗氧化、抗炎和神经营养作用的化合物。其他天然BCC也显示出代谢状况的改善,通常与神经退行性疾病的风险增加有关。然而,近年来,据报道,其他有机硼化合物在与神经退行性变相关的几个过程中具有活性,并且作为AD起源和进展的调节剂特别有吸引力。在这篇小型综述中,收集到的一些数据表明,一些天然BCC可以用作预防剂,而且一些BODIPY作为诊断工具和一些其他BCC(特别是硼酸和频哪醇硼酸酯)作为AD有前景的治疗剂的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Cracked Potential of Boron-containing Compounds in Alzheimer's Disease.

Alzheimer's disease (AD) is a relevant neurodegenerative disease worldwide. Its relevancy is mainly due to its high prevalence and high global burden. Metalloids have attracted attention as their serum levels seem to differ between affected patients and healthy individuals. On the other hand, atoms of some metalloids have been included in bioactive molecules, exerting some interesting effects, mainly due to their ameliorative effects in neurodegeneration. In this sense, boron-containing compounds (BCC) have been explored to regulate or prevent neurodegeneration. As an example, boric acid has been reported as a compound with antioxidant, anti-inflammatory and neurotrophic effects. Other natural BCCs have also shown amelioration of metabolic conditions often related to increased risk of neurodegenerative maladies. However, in recent years, additional organoboron compounds have been reported as active in several processes linked to neurodegeneration and especially attractive as regulators of the origin and progression of AD. In this mini-review, some data are collected suggesting that some natural BCC could be used as preventive agents, but also the potential of some BODIPYs as tools for diagnosis and some other BCC (particularly boronic acids and pinacol boronic esters) for acting as promising therapeutic agents for AD.

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