高密度脂蛋白胆固醇与多发性骨髓瘤:一项系统综述和荟萃分析

IF 1.4 Q3 PERIPHERAL VASCULAR DISEASE
Anastasios Makris , Antonia Pagkali , Emmanouil Nikolousis , Theodosios D. Filippatos , Aris P. Agouridis
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引用次数: 0

摘要

背景与目的系统研究高密度脂蛋白胆固醇(HDL-C)与多发性骨髓瘤(MM)之间关系的所有相关证据。方法我们检索PubMed和Cochrane图书馆数据库(截至2022年9月20日),寻找有证据表明MM患者HDL-C的研究。对已发表的HDL-C和其他脂质特征参数在MM中的作用的前瞻性和回顾性研究进行定性综合。此外,对MM病例和对照组之间的HDL-C平均差异(MD)进行了荟萃分析。结果14项研究(3项前瞻性研究,11项回顾性研究),包括895例MM患者,符合本系统综述的条件。10项研究比较了MM患者和健康对照组的HDL-C水平。在这10项研究中(n=17213),汇总分析显示,与健康对照组相比,MM患者的HDL-C水平显著较低(MD:−13.07 mg/dl,95%CI:−17.83,−8.32,p<;0.00001)。关于次要终点,总胆固醇(TC)(MD:−22.19 mg/dl,95%CI:−39.08,−5.30)和载脂蛋白A-I(apoA-I)(−40.20 mg/dl,95%CI:−55.00,−25.39)显著降低,而低密度脂蛋白胆固醇(LDL-C)(MD:−11.33 mg/dl,95%CI:−36.95,14.30)和甘油三酯(MD:9.93 mg/dl、95%CI:–3.40,23.26)的差异没有显著性。结论MM患者的HDL-C、TC和apoA-I水平显著降低。因此,在评估此类患者时应考虑血脂谱参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High-density lipoprotein cholesterol and multiple myeloma: A systematic review and meta-analysis

Background and aims

To systematically investigate all relevant evidence on the association between high-density lipoprotein cholesterol (HDL-C) and multiple myeloma (MM).

Methods

We searched PubMed and Cochrane library databases (up to 20 September 2022) for studies with evidence on HDL-C in patients with MM. A qualitative synthesis of published prospective and retrospective studies for the role of HDL-C and other lipid profile parameters in MM was performed. Additionally, a meta-analysis on HDL-C mean differences (MD) between MM cases and controls was performed.

Results

Fourteen studies (3 prospective, 11 retrospective) including 895 MM patients were eligible for this systematic review. Ten studies compared HDL-C levels in MM patients with healthy controls. In these 10 studies (n = 17,213), pooled analyses showed that MM patients had significantly lower HDL-C levels compared to healthy controls (MD: −13.07 mg/dl, 95% CI: −17.83, −8.32, p < 0.00001). Regarding secondary endpoints, total cholesterol (TC) (MD: −22.19 mg/dl, 95% CI: −39.08, −5.30) and apolipoprotein A-I (apoA-I) (−40.20 mg/dl, 95% CI: −55.00, −25.39) demonstrated significant decreases, while differences in low-density lipoprotein cholesterol (LDL-C) (MD: −11.33 mg/dl, 95% CI: −36.95, 14.30) and triglycerides (MD: 9.93 mg/dl, 95% CI: −3.40, 23.26) were not shown to be significant.

Conclusions

HDL-C, as well as TC and apoA-I, levels are significantly decreased in MM. Hence, lipid profile parameters should be taken into account when assessing such patients.

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来源期刊
Atherosclerosis plus
Atherosclerosis plus Cardiology and Cardiovascular Medicine
CiteScore
2.60
自引率
0.00%
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审稿时长
66 days
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