Nd:YAG激光对根尖周炎患者牙齿肿瘤坏死因子-α、白细胞介素-β和干扰素-γ水平的影响：一项临床研究。

IF 1.3 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Australian Endodontic Journal Pub Date : 2023-09-25 DOI:10.1111/aej.12799

Sevda Durust Baris DMD, Ali Turkyilmaz DMD, PhD, Mehmet Kursat Derici MD

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引用次数: 0

摘要

本研究旨在评估无症状根尖周炎（AP）患者的肿瘤坏死因子-α（TNF-α）、白细胞介素-β（IL-1β）和干扰素-γ（IFN-γ）水平。共有60名参与者被随机分为两组：常规冲洗（对照）和Nd:YAG激光照射。在根管清洁后（第0天）和第1天获得间质液一周后（第7天）。采用酶联免疫吸附法测定TNF-α、IL-1β和IFN-γ水平。使用Mann-Whitney U、连续性校正卡方、Pearson卡方和Fisher精确检验。对照组在第7天观察到细胞因子水平升高，没有统计学显著差异（p > 0.05）。激光组中所有细胞因子水平随时间降低。只有IL-1β水平有显著差异（p

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Effects of Nd: YAG laser on tumour necrosis factor-alpha, interleukin-1beta and interferon-gamma levels in teeth with apical periodontitis: A clinical study

This study aimed to evaluate the levels of tumour necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β) and interferon-gamma (IFN-γ) with asymptomatic apical periodontitis (AP). A total of 60 participants were randomly divided into two groups: the conventional irrigation (control) and the Nd: YAG laser irradiation. The interstitial fluids were obtained after root canal cleaning (day 0) and 1 week later (day 7). The TNF-α, IL-1β and IFN-γ levels were assayed using the enzyme-linked immunosorbent assay. The Mann-Whitney U, continuity correction chi-square, Pearson chi-square and Fisher exact tests were used. An increased level of cytokines on day 7 in the control group was observed, without statistically significant differences (p > 0.05). All cytokine levels decreased over time in the laser group. Only the IL-1β level showed a significant difference (p < 0.05). Nd: YAG irradiation has a positive effect on decreasing the proinflammatory cytokine level and may help to control infection in teeth with AP.

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来源期刊

Australian Endodontic Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.50

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues. The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses. The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.