[由适应原富集的给定脂肪酸组合物的创新扩散的疗效的临床评估]。

Q2 Medicine
Voprosy pitaniia Pub Date : 2023-01-01 Epub Date: 2023-06-30 DOI:10.33029/0042-8833-2023-92-4-104-113
V I Pilipenko, V A Isakov, S V Morozov, A N Sasunova, A A Goncharov
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引用次数: 0

摘要

适应原是一组能够增加生物体对各种有害影响和压力的非特异性抵抗力的物质。然而,关于它们在特殊饮食用途食品成分中的用途,目前只有有限的数据。该研究的目的是评估包括富含5-羟基色氨酸、L-茶氨酸和γ-氨基丁酸的植物脂肪涂抹的饮食对健康志愿者的记忆力、总体幸福感和情绪状态的影响。材料和方法。已经进行了单中心、单盲随机前瞻性试验,招募了没有明显器质性病理迹象的人。参与者被随机分配接受45g/天的富含5-羟色氨酸(0.67%)、L-茶氨酸(0.56%)和γ-氨基丁酸(0.45%)的标准涂抹(主要组,MG)或45g/天标准涂抹(对照组,CG),持续10天。除此之外,所有参与者都遵循标准饮食。最初,在开始使用该饮食后的第10天,使用HADS焦虑和抑郁量表和Beck抑郁量表(BDI)评估情绪状态,通过SAN问卷评估总体幸福感,根据Lurie方法评估记忆力;使用Krepelin计数测试和Burdon校正测试来评估反应时间和注意力浓度。使用5分Likert视觉模拟量表评估产品的适口性(粘贴)、基线和研究第10天的饥饿感和饱腹感的严重程度。所有测试都是在工作人员的监督下进行的。在研究期间,每天监测不良事件的存在。后果MG组70例,CG组70例。Lurie记忆评分在MG中显著增加(59.9±6.7 vs 58.1±7.4分;p=0.001),但在CG中没有增加(58.0±6.9 vs 57.3±7.3分,p>0.05)。根据SAN问卷,MG的幸福感值(46.9±13.4 vs 44.2±13.5分;p=0.01)和情绪(49.9±12.6 vs 47.4±12.9分;p=0.01)显著增加,而在CG中,情绪类别仅增加(54.4±10.8 vs 52.2±12.1,p=0.04)。研究结束时,CG中的“饱腹感”增加(60.3±22.8 vs 51.5±24.8,p=0.022)和“饥饿感”得分下降(24.1±19.8 vs 29.1±19.4,p=0.02),但CG中没有。两组的其他检查结果、粪便形态及其频率均无显著变化。结论新开发的富含5-羟基色氨酸、L-茶氨酸、γ-氨基丁酸的涂抹物耐受性良好,不影响饥饿感和饱腹感,并改善了记忆力和幸福感参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Clinical evaluation of the efficacy of innovative spread of a given fatty acid composition enriched by adaptogens].

Adaptogens are a group of substances capable to increase the nonspecific resistance of the organism to a wide range of harmful effects and stress. However, only limited data exist on their use in the composition of foods for special dietary uses. The aim of the study was to evaluate the effect of a diet that included vegetable-fat spread enriched with 5-hydroxytryptophan, L-theanine and γ-aminobutyric acid on memory, general well-being and emotional status of healthy volunteers. Material and methods. The single-center, single-blind randomized prospective trial that enrolled persons without signs of significant organic pathology have been performed. Participants were randomly allocated to receive either 45 g/day standard spread enriched with 5-hydroxytryptophan (0.67%), L-theanine (0.56%) and γ-aminobutyric acid (0.45%) (main group, MG) or 45 g/day standard spread (control group, CG) for 10 days. Beside this, all participants followed a standard diet. Initially, as well as on the 10th day after the start of using the diet, the emotional state was assessed using the HADS anxiety and depression scale and Beck's depression inventory (BDI), general well-being by SAN questionnaire, memory according to the Lurie method; reaction time and attention concentration were assessed using the Krepelin counting test and the Burdon correction test. A 5-point Likert visual-analogue scale was used to assess the palatability (pasting) of the product, the severity of feelings of hunger and satiety at the baseline and on the 10th day of the study. All tests were performed under the supervision of staff. During the study, daily monitoring of the presence of adverse events was performed. Results. There were 70 subjects in MG and 70 in CG. Lurie memory score significantly increased in the MG (59.9±6.7 vs 58.1±7.4 points at the baseline; p=0.001), but not in the CG (58.0±6.9 vs 57.3±7.3 points, p>0.05). According to the SAN questionnaire, significant increase of well-being values (46.9±13.4 vs 44.2±13.5 points; p=0.01) and mood (49.9±12.6 vs 47.4±12.9 points; p=0.01) was found in MG, while in CG there was an increase of the mood category only (54.4±10.8 vs 52.2±12.1, p=0.04). At the end of the study an increase of «Satiety» (60.3±22.8 vs 51.5±24.8, p=0.022) and decrease of «Hunger» score (24.1±19.8 vs 29.1±19.4, p=0.02) were revealed in CG but not in the CG. No significant change was found by the results of other tests, stool form and its frequency in both groups. Conclusion. Newly developed spread enriched with 5-hydroxytryptophan, L-theanine, γ-aminobutyric acid was well-tolerated, did not affect the feeling of hunger and satiety, and improved memory and well-being parameters.

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Voprosy pitaniia
Voprosy pitaniia Medicine-Medicine (all)
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