[北极地区居民维生素A与甲状腺功能的关系]。

Q2 Medicine
Voprosy pitaniia Pub Date : 2023-01-01 Epub Date: 2023-06-30 DOI:10.33029/0042-8833-2023-92-4-66-73
A E Elfimova, E V Tipisova, F A Bichkaeva, I N Molodovskaya, O S Vlasova, T B Gretskaya
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引用次数: 0

摘要

目前甲状腺疾病的患病率不断上升,因此了解影响甲状腺活动的因素非常重要。维生素A(视黄醇)是一种脂溶性维生素,具有激素样作用,可影响垂体促甲状腺激素的表达和甲状腺激素的合成。这项研究的目的是研究俄罗斯联邦北极地区居民的维生素A血清水平及其与甲状腺状况的关系,具体取决于性别。材料和方法。在一项单中心观察性横断面研究中,对阿尔汉格尔斯克地区304名明显健康的村庄居民(103名男性和201名女性)进行了检查。荧光法测定血清维生素A浓度,酶免疫法测定甲状腺参数含量。计算甲状腺积分指数(ITI)和碘甲状腺原氨酸外周转化指数(IPC)。根据维生素A的四分位数,受试者被分为4组。通过降低维生素A浓度来计算患亚临床甲状腺功能减退症的相对风险。结果。维生素A含量为1.97(1.18;2.97)μmol/l。女性人群的视黄醇水平明显低于男性人群(1.85μmol/l vs 2.27μmol/l,P结论。在北极地区的居民中,维生素A的含量在参考值范围内,但24.3%的男性的维生素A水平高于正常水平。在女性中,视黄醇的浓度明显较低,其水平低于1.39μmol/l会使患亚临床甲状腺功能减退症的风险增加2.0倍北方居民会导致甲状腺素水平降低,碘甲状腺原氨酸的外周转化率增加,这在男性中更为明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Relationship of vitamin A and thyroid function in Arctic residents].

At the present time the prevalence of thyroid diseases keeps growing, so knowledge of the factors affecting thyroid activity is very important. Vitamin A (retinol) is a fat-soluble vitamin with a hormone-like effect that can influence both the expression of thyroidstimulating hormone in the pituitary gland and the synthesis of thyroid hormones. The aim of the research was to study vitamin A serum level and its relationship with the thyroid profile in residents of the Arctic zone of the Russian Federation, depending on gender. Material and methods. In the course of a single-center observational cross-sectional study, 304 apparently healthy residents of villages in the Arkhangelsk region (103 men and 201 women) were examined. The serum concentration of vitamin A was determined by the fluorometric method, and the content of thyroid parameters was determined by the enzyme immunoassay. The integral thyroid index (ITI) and the index of peripheral conversion of iodothyronines (IPC) were calculated. The subjects were divided into 4 groups depending on the quartile of vitamin A. The relative risk of developing subclinical hypothyroidism was calculated with a reduced concentration of vitamin A. Results. The content of vitamin A was 1.97 (1.18; 2.97) μmol/l. Retinol levels in the female population were significantly lower than in the male population (1.85 vs 2.27 μmol/l, p<0.0001). Women in group 1 compared with group 4 showed significantly higher levels of thyrotropin (2.33 vs 1.40 μIU/ml, p=0.0002) and thyroxin (109.8 vs 99.4 nmol/l, p=0.010), while the ITI values, on the contrary, were the lowest (8.12 and 13.85 c.u., p=0.0002). The relative risk calculation showed that vitamin A levels below 1.39 μmol/L increase the risk of subclinical hypothyroidism in women by 2.01 times [95% confidence interval 1.07-3.78]. Men in group 4 compared with group 1 showed a lower content of thyroxin (83.0 vs 109.2 nmol/l, p=0.009) against the background of higher IPC values (0.019 vs 0.016 c.u., p=0.046). Conclusion. In the inhabitants of the Arctic, the content of vitamin A is within the reference values, however, in 24.3% of men, its level is above the norm. In women, the concentration of retinol is significantly lower, and its level of less than 1.39 μmol/l increases the risk of developing subclinical hypothyroidism by 2.0 times. Increased values of vitamin A in the inhabitants of the North cause lower levels of thyroxine and an increase in the peripheral conversion of iodothyronines, which is more pronounced in men.

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Voprosy pitaniia
Voprosy pitaniia Medicine-Medicine (all)
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