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引用次数: 0
摘要
背景：近年来，早期姑息治疗（PC）因改善晚期癌症患者的健康相关结果而受到越来越多的关注，但先前的研究结果并不一致。目的：本研究旨在使用荟萃分析和试验序列分析来评估早期PC对晚期癌症患者健康相关结果的影响。方法：从开始到2023年3月，在PubMed、Web of Science、Embase和Cochrane图书馆搜索所有英文出版物，但研究类型为随机对照试验。结果：结果显示，早期PC对生活质量、护理满意度和症状负担减轻有积极影响。然而，早期PC对焦虑或生存没有显著影响。试验序列分析结果表明，早期PC对生活质量的影响是稳定的。讨论：这项系统综述表明，早期PC可以对晚期癌症患者的健康相关结果产生积极影响。早期PC可以在临床环境中广泛使用，以改善晚期癌症的健康相关结果。然而，由于试验序列分析的结果，需要进一步设计良好的、临床的、随机的、样本量更大的对照试验来得出明确的结论。
Meta-Analysis of Effects of Early Palliative Care on Health-Related Outcomes Among Advanced Cancer Patients.
Background: Early palliative care (PC) has received more attention for improving health-related outcomes for advanced cancer patients in recent years, but the results of previous studies are inconsistent.
Objectives: This study aimed to use meta-analysis and trial sequence analysis to evaluate the effect of early PC on health-related outcomes of advanced cancer patients.
Methods: All English publications were searched in PubMed, Web of Science, Embase, and the Cochrane Library from inception to March 2023, with a restriction that the study type was a randomized controlled trial.
Results: The results showed that early PC positively affected quality of life, satisfaction with care, and symptom burden reduction. However, early PC had no significant effect on anxiety or survival. Trial sequence analysis results showed that the effect of early PC on the quality of life was stable.
Discussion: This systematic review suggested that early PC could positively affect health-related outcomes for advanced cancer patients. Early PC can be used widely in clinical settings to improve health-related outcomes of advanced cancer. However, because of the trial sequence analysis results, further well-designed, clinical, randomized controlled trials with larger sample sizes are necessary to draw definitive conclusions.
期刊介绍：
Nursing Research is a peer-reviewed journal celebrating over 60 years as the most sought-after nursing resource; it offers more depth, more detail, and more of what today''s nurses demand. Nursing Research covers key issues, including health promotion, human responses to illness, acute care nursing research, symptom management, cost-effectiveness, vulnerable populations, health services, and community-based nursing studies. Each issue highlights the latest research techniques, quantitative and qualitative studies, and new state-of-the-art methodological strategies, including information not yet found in textbooks. Expert commentaries and briefs are also included. In addition to 6 issues per year, Nursing Research from time to time publishes supplemental content not found anywhere else.
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