作为“MYC促进者”的长非编码RNA。

IF 2.7 Q2 PATHOLOGY

Pathophysiology Pub Date : 2023-09-01 DOI:10.3390/pathophysiology30030030

Daniel García-Caballero, Jonathan R Hart, Peter K Vogt

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引用次数: 0

摘要

在这篇文章中，我们讨论了一类MYC相互作用的lncRNA（长非编码RNA），它们共享以下标准：它们是MYC的直接转录靶点。它们的表达与MYC的表达相协调。它们是MYC驱动的细胞持续增殖所必需的，并且它们对细胞存活不是必需的。我们将这些lncRNA称为“MYC促进因子”，并讨论了这类lncRNA的两个代表性成员，SNHG17（小核RNA宿主基因）和LNROP（POU2F2的长非编码调节因子）。我们还提出了lncRNA在MYC介导的转录调控中的作用的一般假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Long Non-Coding RNAs as "MYC Facilitators".

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Long Non-Coding RNAs as "MYC Facilitators".

In this article, we discuss a class of MYC-interacting lncRNAs (long non-coding RNAs) that share the following criteria: They are direct transcriptional targets of MYC. Their expression is coordinated with the expression of MYC. They are required for sustained MYC-driven cell proliferation, and they are not essential for cell survival. We refer to these lncRNAs as "MYC facilitators" and discuss two representative members of this class of lncRNAs, SNHG17 (small nuclear RNA host gene) and LNROP (long non-coding regulator of POU2F2). We also present a general hypothesis on the role of lncRNAs in MYC-mediated transcriptional regulation.

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来源期刊

Pathophysiology Medicine-Pathology and Forensic Medicine

CiteScore

3.10

自引率

0.00%

发文量

期刊介绍： Pathophysiology is an international journal which publishes papers in English which address the etiology, development, and elimination of pathological processes. Contributions on the basic mechanisms underlying these processes, model systems and interdisciplinary approaches are strongly encouraged.