巨噬细胞与骨愈合微环境的相互作用:机制和生物材料。

IF 5.1 2区 医学 Q2 CELL & TISSUE ENGINEERING
Tissue Engineering. Part B, Reviews Pub Date : 2024-06-01 Epub Date: 2023-10-26 DOI:10.1089/ten.TEB.2023.0157
Xiaoxuan Lu, Jike Gao, Weimin Bao, Jianguang Xu, Xiaoyu Sun, Yuanyin Wang, Bang Li
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引用次数: 0

摘要

广泛的骨折会严重影响健康和生活质量,无法轻易自然愈合,尤其是在患者有潜在疾病或正在衰老的情况下。解决此类骨折最有前途的方法是通过骨组织工程进行骨再生。骨再生是一个复杂的过程,包括三个不同的阶段:炎症、修复和重塑。巨噬细胞在参与骨再生每个阶段的各种细胞之间起着桥接作用,与不同的微环境相互作用,促进骨愈合过程。尽管巨噬细胞的起源和功能已经得到了广泛的研究,但它们与骨愈合微环境相互作用的机制仍有待探索,包括微环境变化与巨噬细胞重编程的关系以及巨噬细胞在微环境中细胞中的作用。本文综述了骨再生过程和巨噬细胞与骨愈合微环境相互作用的最新研究进展,并讨论了通过调节巨噬细胞促进骨再生以治疗骨损伤和骨丢失的新生物学策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interaction of Macrophages with Bone Healing Microenvironment: Mechanism and Biomaterials.

Extensive bone fractures, which can seriously impact both health and quality of life, cannot easily heal naturally, especially if the patient has an underlying medical condition or is aging. The most promising approach to addressing such fractures is bone regeneration through bone tissue engineering. Bone regeneration is a complex process that consists of three distinct phases: inflammation, repair, and remodeling. Macrophages play a bridging role between the various cells involved in each stage of bone regeneration, interacting with different microenvironments and advancing the bone healing process. Although the origin and function of macrophages have been extensively studied, the mechanisms underlying their interaction with the bone healing microenvironment remain unexplored, including the association of microenvironmental changes with macrophage reprogramming and the role of macrophages in cells in the microenvironment. This review summarizes the bone regeneration process and recent advances in research on interactions between macrophages and the bone healing microenvironment and discusses novel biological strategies to promote bone regeneration by modulating macrophages for the treatment of bone injury and loss.

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来源期刊
Tissue Engineering. Part B, Reviews
Tissue Engineering. Part B, Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
12.80
自引率
1.60%
发文量
150
期刊介绍: Tissue Engineering Reviews (Part B) meets the urgent need for high-quality review articles by presenting critical literature overviews and systematic summaries of research within the field to assess the current standing and future directions within relevant areas and technologies. Part B publishes bi-monthly.
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