泛素化在脂质代谢中的普遍作用。

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-05-01 Epub Date: 2023-09-26 DOI:10.1016/j.tcb.2023.09.001

Melanie Loix, Noam Zelcer, Jeroen F J Bogie, Jerome J A Hendriks

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引用次数: 0

摘要

脂质是在细胞生理学中发挥关键作用的重要分子，作为结构成分，用于储存能量和信号转导。因此，脂质稳态的有效调节和维持对正常的细胞和组织功能至关重要。在过去的十年里，越来越多的研究表明，泛素化在调节脂质代谢不同方面关键参与者的稳定性方面具有重要意义。这篇综述描述了泛素信号对脂质代谢调节的最新见解，讨论了泛素化如何在以脂质失调为特征的疾病中被靶向，并确定了需要进一步研究的领域。

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The ubiquitous role of ubiquitination in lipid metabolism.

Lipids are essential molecules that play key roles in cell physiology by serving as structural components, for storage of energy, and in signal transduction. Hence, efficient regulation and maintenance of lipid homeostasis are crucial for normal cellular and tissue function. In the past decade, increasing research has shown the importance of ubiquitination in regulating the stability of key players in different aspects of lipid metabolism. This review describes recent insights into the regulation of lipid metabolism by ubiquitin signaling, discusses how ubiquitination can be targeted in diseases characterized by lipid dysregulation, and identifies areas that require further research.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.