新型冠状病毒和疫苗接种对格林-巴利综合征有什么影响?

IF 4.6 2区 医学 Q1 NEUROSCIENCES
Molecular Neurobiology Pub Date : 2024-12-01 Epub Date: 2023-09-20 DOI:10.1007/s12035-023-03638-8
Yinuo Chen, Kezheng Li, Wenjing Lv, Jiali Xie, Yuqin Qian, Can Cui, Binbin Deng
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引用次数: 0

摘要

过去3年,由严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的新冠肺炎大流行在全球范围内造成了毁灭性的医疗和经济后果。随着疫情进入新阶段,有必要考虑对格林-巴利综合征(GBS)等罕见疾病的潜在影响,自2020年1月报告首例与新冠肺炎相关的GBS病例以来,格林-巴利综合症一直与新冠肺炎密切相关。在诊断类型和临床表现方面,与新冠肺炎相关的GBS和没有新冠肺炎的GBS之间存在显著差异。此外,随着新冠肺炎疫苗的广泛使用,有报道称GBS在接种后不久发生,尽管其罕见,但仍需要密切关注。这篇综述还探讨了与GBS风险增加相关的疫苗,提供了可能指导疫苗接种政策和临床实践的见解。为了提供这些发现的可视化摘要,我们包含了一个图形摘要。本文将讨论新型冠状病毒阳性后GBS患者的特征性表现以及几种新冠肺炎疫苗的安全性。本文首先对新型冠状病毒相关GBS的流行病学方面进行了全面阐述和讨论。例如,从同一人群来看,新冠肺炎阳性人群中GBS的预期发病率(人/10万人/年)约为新冠肺炎阴性人群的43倍,GBS的发病率显著增加。其次,总结和比较了COVID-19阴性GBS患者和SARS-CoV-2-GBS(SC2-GBS)患者的临床特点。再次,本文回顾了目前新冠肺炎疫苗接种后不良事件中的GBS病例,并从GBS事件的发生率、患者年龄比例、发病间隔等多个角度进行了分析和讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
What Is the Impact of the Novel Coronavirus and the Vaccination on Guillain-Barre Syndrome?

The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has resulted in devastating medical and economic consequences worldwide over the past 3 years. As the pandemic enters a new stage, it is essential to consider the potential impact on rare diseases such as Guillain-Barre syndrome (GBS), which has been intimately associated with COVID-19 since the first COVID-19-related GBS case was reported in January 2020. There are notable differences between COVID-19-related GBS and GBS without COVID-19 in terms of diagnostic types and clinical manifestations. Furthermore, with the widespread administration of COVID-19 vaccines, there have been reports of GBS occurring shortly after vaccination, which requires close attention despite its rarity. This review also explores the vaccines associated with heightened GBS risks, offering insights that may guide vaccination policies and clinical practice. To provide a visual summary of these findings, we have included a graphical abstract.

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来源期刊
Molecular Neurobiology
Molecular Neurobiology 医学-神经科学
CiteScore
9.00
自引率
2.00%
发文量
480
审稿时长
1 months
期刊介绍: Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.
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