从老花Gypsophila oldhamiana花中分离得到一对非对映异构体C-呋喃葡萄糖基黄酮。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-01-01 Epub Date: 2023-09-26 DOI:10.1080/14786419.2023.2261138

Hai-Yan Wu, Hong-Min Xia, Wan-Jin Zheng

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引用次数: 0

摘要

从老花Gypsophila oldhamiana的花中分离到两个新的C-呋喃糖基黄酮-芹菜素6-C-β-呋喃糖苷（1）和芹菜素6-C-α-呋喃糖糖苷（2）以及四个已知化合物（3-6）。它们的结构是在广泛的光谱分析的基础上阐明的。评估了这些化合物对四种人类癌症细胞系的细胞毒性活性，并且没有表现出任何显著的生物活性（IC50值>10 μM）。

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A pair of diastereoisomeric C-glucofuranosyl flavones from the flowers of Gypsophila oldhamiana.

Two new C-glucofuranosyl flavones apigenin 6-C-β-glucofuranoside (1) and apigenin 6-C-α-glucofuranoside (2) together with four known compounds (3-6) were isolated from the flowers of Gypsophila oldhamiana. Their structures were elucidated on the basis of extensive spectroscopic analyses. These compounds were evaluated for the cytotoxic activities against four human cancer cell lines and did not exhibit any significant bioactivities (IC₅₀ values > 10 μM).

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.