噬菌体作为递送载体和噬菌体展示。

3区生物学 Q2 Biochemistry, Genetics and Molecular Biology

Progress in Molecular Biology and Translational Science Pub Date : 2023-01-01 Epub Date: 2023-04-10 DOI:10.1016/bs.pmbts.2023.03.013

Salsabil Makky, Fatma Abdelrahman, Maheswaran Easwaran, Anan Safwat, Ayman El-Shibiny

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引用次数: 0

摘要

噬菌体（简称噬菌体）是细菌的天敌，可以作为抗生素的替代品来克服抗生素耐药性的挑战。然而，在最近的科学史上，噬菌体被用于不同的分子工具，并被用于多种治疗和诊断方法。此外，由于噬菌体的高度特异性宿主范围仅限于原核生物，噬菌体颗粒可以用作安全的递送载体和展示系统。本章介绍了不同的噬菌体展示系统，以及噬菌体展示作为分子和治疗工具在开发疫苗、抗菌和抗癌治疗中的各种应用。

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Phages as delivery vehicles and phage display.

Bacteriophages (Phages in short) were introduced as the natural enemy of bacteria that may act as alternatives to antibiotics to overcome the challenge of antibiotic resistance. However, in the recent history of science, phages have been employed in different molecular tools and used in numerous therapeutic and diagnostic approaches. Furthermore, thanks to the phage`s highly specific host range limited to prokaryotes, phage particles can be used as safe delivery vehicles and display systems. In this chapter, different phage display systems are introduced, in addition to various applications of phage display as a molecular and therapeutic tool in developing vaccines, antibacterial, and anti-cancer treatments.

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来源期刊

Progress in Molecular Biology and Translational Science BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

5.00

自引率

0.00%

发文量

110

审稿时长

4-8 weeks

期刊介绍： Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientiﬁc importance. If today you read an Article or Letter in　Nature　or a Research Article or Report in　Science　reporting ﬁndings of exceptional importance, you likely will ﬁnd comprehensive coverage of that research area in a future　PMBTS　volume.