妊娠期暴露于环境颗粒物：对婴儿端粒长度的影响。

medRxiv : the preprint server for health sciences Pub Date : 2024-02-12 DOI:10.1101/2023.09.17.23295692

Nina E Ahlers, Jue Lin, Sandra J Weiss

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引用次数: 0

摘要

背景：越来越多的证据表明，空气污染可能会影响胎儿的发育，并对以后的健康产生潜在影响。端粒长度（TL）的改变是胎儿暴露于空气污染与疾病发展之间联系的一种可能的中介机制。然而，为数不多的探索产前污染与婴儿TL之间关系的研究评估了不同的妊娠期，结果喜忧参半。本研究的目的是检验妊娠1、2和3个月大的婴儿TL在产前暴露于空气污染物PM2.5的差异关系。方法：女性（n=74）在妊娠晚期被招募到产科诊所。从地区空气质量管理区获得了每个妇女居住区在每个妊娠期的PM2.5暴露数据。出生后一个月，从婴儿身上采集唾液样本，为端粒测定提供DNA。女性完成了关于生活中压力源、感知压力、抑郁和社会人口统计的问卷调查，作为协变量纳入。采用多元线性回归方法对目标进行分析。结果：孕2（β=0.31，p=0.003）和孕3（β=0.24，p=0.02）暴露于PM2.5与较长的婴儿TL相关。孕1的暴露与TL无关。母亲抑郁、年龄和婴儿女性的共同变量也与较长的TL相关。模型中的变量占TL方差的34%（F=10.58，p=.000）。讨论：胎儿对污染的较长端粒编程可能对新生儿适应空气质量不理想的产后环境具有适应性价值。或者，考虑到较长的TL与癌症等疾病之间已建立的联系，较长的端粒可能会预测后期的健康风险。未来的研究需要解决产前污染如何与TL相互作用，从而随着时间的推移影响健康。

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WITHDRAWN: Exposure to Ambient Particulate Matter during Pregnancy: Implications for Infant Telomere Length.

This manuscript has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author. The authors have an approved version for citation that is peer reviewed. Ahlers, N.E.; Lin, J.; Weiss, S.J. Exposure to Ambient Particulate Matter during Pregnancy: Implications for Infant Telomere Length. Air 2024, 2, 24-37. https://doi.org/10.3390/air2010002.

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medRxiv : the preprint server for health sciences

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