cGAS-STING信号在介导眼部炎症中的新作用。

IF 4.7 3区 医学 Q2 IMMUNOLOGY
Journal of Innate Immunity Pub Date : 2023-01-01 Epub Date: 2023-10-03 DOI:10.1159/000533897
Linbin Zhou, Bo Man Ho, Hoi Ying Emily Chan, Yan Tong, Lin Du, Jing Na He, Danny Siu-Chun Ng, Clement C Tham, Chi Pui Pang, Wai Kit Chu
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引用次数: 0

摘要

环状GMP-AMP(cGAMP)合酶(cGAS)是胞质DNA的传感器,通过产生第二信使cGAMP和随后激活干扰素基因刺激因子(STING)来识别细胞质核酸以激活先天免疫反应。cGAS-STING信号在人类所有重要器官中具有多种免疫和生理功能。它介导对含有DNA的病原体感染的保护性先天免疫防御,通过检测肿瘤衍生的DNA赋予固有的抗肿瘤免疫,并在自身基因组和线粒体DNA的胞质泄漏引起异常激活时引发自身免疫和炎症性疾病。这些功能的破坏与各种免疫和神经退行性疾病的病理生理学有关。最近的证据表明,cGAS-STING信号在介导眼部炎症和炎症相关疾病的炎症反应中发挥着重要作用,如角膜炎、糖尿病视网膜病变、年龄相关性黄斑变性和葡萄膜炎。在这篇综述中,我们总结了最近出现的cGAS-STING信号在介导眼部炎症反应和影响这些复杂眼病发病机制方面的证据。我们试图为研究cGAS-STING信号在眼部炎症中的未来方向提供有见地的视角。了解cGAS-STING信号如何被调节以介导眼部炎症反应,将有助于未来开发治疗眼部炎症和自身免疫的新治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Emerging Roles of cGAS-STING Signaling in Mediating Ocular Inflammation.

Emerging Roles of cGAS-STING Signaling in Mediating Ocular Inflammation.

Emerging Roles of cGAS-STING Signaling in Mediating Ocular Inflammation.

Cyclic GMP-AMP (cGAMP) synthase (cGAS), a sensor of cytosolic DNA, recognizes cytoplasmic nucleic acids to activate the innate immune responses via generation of the second messenger cGAMP and subsequent activation of the stimulator of interferon genes (STINGs). The cGAS-STING signaling has multiple immunologic and physiological functions in all human vital organs. It mediates protective innate immune defense against DNA-containing pathogen infection, confers intrinsic antitumor immunity via detecting tumor-derived DNA, and gives rise to autoimmune and inflammatory diseases upon aberrant activation by cytosolic leakage of self-genomic and mitochondrial DNA. Disruptions in these functions are associated with the pathophysiology of various immunologic and neurodegenerative diseases. Recent evidence indicates important roles of the cGAS-STING signaling in mediating inflammatory responses in ocular inflammatory and inflammation-associated diseases, such as keratitis, diabetic retinopathy, age-related macular degeneration, and uveitis. In this review, we summarize the recently emerging evidence of cGAS-STING signaling in mediating ocular inflammatory responses and affecting pathogenesis of these complex eye diseases. We attempt to provide insightful perspectives on future directions of investigating cGAS-STING signaling in ocular inflammation. Understanding how cGAS-STING signaling is modulated to mediate ocular inflammatory responses would allow future development of novel therapeutic strategies to treat ocular inflammation and autoimmunity.

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来源期刊
Journal of Innate Immunity
Journal of Innate Immunity 医学-免疫学
CiteScore
10.50
自引率
1.90%
发文量
35
审稿时长
7.5 months
期刊介绍: The ''Journal of Innate Immunity'' is a bimonthly journal covering all aspects within the area of innate immunity, including evolution of the immune system, molecular biology of cells involved in innate immunity, pattern recognition and signals of ‘danger’, microbial corruption, host response and inflammation, mucosal immunity, complement and coagulation, sepsis and septic shock, molecular genomics, and development of immunotherapies. The journal publishes original research articles, short communications, reviews, commentaries and letters to the editors. In addition to regular papers, some issues feature a special section with a thematic focus.
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