间充质基质细胞作为脂肪组织重塑的导体。

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2023-09-01 Epub Date: 2023-10-05 DOI:10.1101/gad.351069.123

Jessica Cannavino, Rana K Gupta

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引用次数: 0

摘要

脂肪组织表现出显著的扩张、收缩和重塑能力，以应对生理和环境条件的变化。在这里，我们描述了我们对功能不同的组织驻留间充质基质细胞亚群如何协调生理和病理生理脂肪组织重塑的几个方面的理解的最新进展，特别关注对能量过剩和环境温度变化的适应。脂肪组织重塑的研究为了解基质细胞的功能多样性提供了一种载体，并提供了一个透镜，通过它可以很容易地观察组织重组的几个可推广的方面。

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Mesenchymal stromal cells as conductors of adipose tissue remodeling.

Adipose tissue exhibits a remarkable capacity to expand, contract, and remodel in response to changes in physiological and environmental conditions. Here, we describe recent advances in our understanding of how functionally distinct tissue-resident mesenchymal stromal cell subpopulations orchestrate several aspects of physiological and pathophysiological adipose tissue remodeling, with a particular focus on the adaptations that occur in response to changes in energy surplus and environmental temperature. The study of adipose tissue remodeling provides a vehicle to understand the functional diversity of stromal cells and offers a lens through which several generalizable aspects of tissue reorganization can be readily observed.

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).