人类核糖体DNA中的非典型DNA结构。

IF 2.1 4区生物学 Q4 CELL BIOLOGY

Histochemistry and Cell Biology Pub Date : 2023-12-01 Epub Date: 2023-09-26 DOI:10.1007/s00418-023-02233-1

Evgeny Smirnov, Pavla Molínová, Nikola Chmúrčiaková, Tomáš Vacík, Dušan Cmarko

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引用次数: 1

摘要

非规范结构（NCS）是指不同于Watson和Crick所描述的B构象的各种形式的DNA。已经发现，这些结构是基因组的常见组成部分，积极参与其基本功能。本文综述了人类核糖体DNA（rDNA）中出现或可能出现的9种NCS：超螺旋结构、R-环、G-四链体、i-基序、DNA三链体、十字形结构、DNA气泡以及A和Z DNA构象。我们讨论了它们产生的条件，包括它们的序列特异性、在基因座内的分布、动力学以及在细胞中的有益和有害作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Non-canonical DNA structures in the human ribosomal DNA.

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Non-canonical DNA structures in the human ribosomal DNA.

Non-canonical structures (NCS) refer to the various forms of DNA that differ from the B-conformation described by Watson and Crick. It has been found that these structures are usual components of the genome, actively participating in its essential functions. The present review is focused on the nine kinds of NCS appearing or likely to appear in human ribosomal DNA (rDNA): supercoiling structures, R-loops, G-quadruplexes, i-motifs, DNA triplexes, cruciform structures, DNA bubbles, and A and Z DNA conformations. We discuss the conditions of their generation, including their sequence specificity, distribution within the locus, dynamics, and beneficial and detrimental role in the cell.

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来源期刊

Histochemistry and Cell Biology 生物-细胞生物学

CiteScore

4.90

自引率

8.70%

发文量

112

审稿时长

1 months

期刊介绍： Histochemistry and Cell Biology is devoted to the field of molecular histology and cell biology, publishing original articles dealing with the localization and identification of molecular components, metabolic activities and cell biological aspects of cells and tissues. Coverage extends to the development, application, and/or evaluation of methods and probes that can be used in the entire area of histochemistry and cell biology.