低剂量纳曲酮治疗慢性疼痛有效吗？

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Family Practice Pub Date : 2023-09-01 DOI:10.12788/jfp.0654

Roxanne Radi, Harriet Huang, Jason Rivera, Corey Lyon, Kristen DeSanto

{"title":"低剂量纳曲酮治疗慢性疼痛有效吗？","authors":"Roxanne Radi, Harriet Huang, Jason Rivera, Corey Lyon, Kristen DeSanto","doi":"10.12788/jfp.0654","DOIUrl":null,"url":null,"abstract":"YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT]). Low-dose naltrexone significantly reduced pain by 32% in inflammatory conditions and 44% in neuropathic conditions (SOR, B; single retrospective cohort study). Doses as low as 5.4 mg were found to reduce pain in 95% of patients with fibromyalgia (SOR, B; single prospective dose-response study).","PeriodicalId":54836,"journal":{"name":"Journal of Family Practice","volume":"72 7","pages":"320-321"},"PeriodicalIF":1.3000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Is low-dose naltrexone effective in chronic pain management?\",\"authors\":\"Roxanne Radi, Harriet Huang, Jason Rivera, Corey Lyon, Kristen DeSanto\",\"doi\":\"10.12788/jfp.0654\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT]). Low-dose naltrexone significantly reduced pain by 32% in inflammatory conditions and 44% in neuropathic conditions (SOR, B; single retrospective cohort study). Doses as low as 5.4 mg were found to reduce pain in 95% of patients with fibromyalgia (SOR, B; single prospective dose-response study).\",\"PeriodicalId\":54836,\"journal\":{\"name\":\"Journal of Family Practice\",\"volume\":\"72 7\",\"pages\":\"320-321\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Family Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.12788/jfp.0654\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Family Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12788/jfp.0654","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

摘要

是的。低剂量纳曲酮在治疗疼痛的糖尿病神经病变方面与阿米替林一样有效，并且具有优越的安全性（推荐强度[SOR]，B；单一随机对照试验[RCT]）。低剂量纳曲酮在炎症条件下可显著减轻32%的疼痛，在神经性条件下可明显减轻44%的疼痛（SOR，B；单一回顾性队列研究）。发现低至5.4 mg的剂量可减轻95%纤维肌痛患者的疼痛（SOR，B；单一前瞻性剂量反应研究）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Is low-dose naltrexone effective in chronic pain management?

YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT]). Low-dose naltrexone significantly reduced pain by 32% in inflammatory conditions and 44% in neuropathic conditions (SOR, B; single retrospective cohort study). Doses as low as 5.4 mg were found to reduce pain in 95% of patients with fibromyalgia (SOR, B; single prospective dose-response study).

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Family Practice PRIMARY HEALTH CARE-MEDICINE, GENERAL & INTERNAL

CiteScore

0.50

自引率

0.00%

发文量

130

审稿时长

6-12 weeks

期刊介绍： JFP is a peer-reviewed medical journal specifically intended to meet the needs of the specialty of family medicine. JFP is delivered to more than 95,000 family physicians as well as general practitioners and osteopaths in primary care.