{"title":"新型整合和偶联元件Tn7563对脆弱拟杆菌菌株中cfiA碳青霉烯酶基因的上调。","authors":"Tore Taksdal Stubhaug , Nermin Zecic , Dagfinn Skaare","doi":"10.1016/j.anaerobe.2023.102785","DOIUrl":null,"url":null,"abstract":"<div><p>We describe Tn<em>7563</em>, a 31,844-bp integrative and conjugative element (ICE) carrying promoters upregulating the <em>cfiA</em> carbapenemase gene in <em>Bacteroides fragilis</em> strain Tbg-22. Excision and circularization of Tn<em>7563</em> was demonstrated by PCR. Previously, only insertion sequences (IS) have been shown to carry mobile promoters for <em>cfiA</em>.</p></div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Upregulation of the cfiA carbapenemase gene in a Bacteroides fragilis strain by the novel integrative and conjugative element Tn7563\",\"authors\":\"Tore Taksdal Stubhaug , Nermin Zecic , Dagfinn Skaare\",\"doi\":\"10.1016/j.anaerobe.2023.102785\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We describe Tn<em>7563</em>, a 31,844-bp integrative and conjugative element (ICE) carrying promoters upregulating the <em>cfiA</em> carbapenemase gene in <em>Bacteroides fragilis</em> strain Tbg-22. Excision and circularization of Tn<em>7563</em> was demonstrated by PCR. Previously, only insertion sequences (IS) have been shown to carry mobile promoters for <em>cfiA</em>.</p></div>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S107599642300094X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S107599642300094X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Upregulation of the cfiA carbapenemase gene in a Bacteroides fragilis strain by the novel integrative and conjugative element Tn7563
We describe Tn7563, a 31,844-bp integrative and conjugative element (ICE) carrying promoters upregulating the cfiA carbapenemase gene in Bacteroides fragilis strain Tbg-22. Excision and circularization of Tn7563 was demonstrated by PCR. Previously, only insertion sequences (IS) have been shown to carry mobile promoters for cfiA.
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