新型整合和偶联元件Tn7563对脆弱拟杆菌菌株中cfiA碳青霉烯酶基因的上调。

IF 2.5 3区生物学 Q3 MICROBIOLOGY

Anaerobe Pub Date : 2023-10-01 DOI:10.1016/j.anaerobe.2023.102785

Tore Taksdal Stubhaug , Nermin Zecic , Dagfinn Skaare

引用次数: 0

摘要

我们描述了Tn7563，一种31844bp的整合和偶联元件（ICE），携带启动子上调脆弱拟杆菌菌株Tbg-22中的cfiA碳青霉烯酶基因。通过PCR证实Tn7563的切除和环化。以前，只有插入序列（IS）被证明携带cfiA的移动启动子。

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Upregulation of the cfiA carbapenemase gene in a Bacteroides fragilis strain by the novel integrative and conjugative element Tn7563

We describe Tn7563, a 31,844-bp integrative and conjugative element (ICE) carrying promoters upregulating the cfiA carbapenemase gene in Bacteroides fragilis strain Tbg-22. Excision and circularization of Tn7563 was demonstrated by PCR. Previously, only insertion sequences (IS) have been shown to carry mobile promoters for cfiA.

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.