光遗传学视力恢复。

IF 7.8 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Cold Spring Harbor perspectives in medicine Pub Date : 2024-08-01 DOI:10.1101/cshperspect.a041660

Volker Busskamp, Botond Roska, Jose-Alain Sahel

{"title":"光遗传学视力恢复。","authors":"Volker Busskamp, Botond Roska, Jose-Alain Sahel","doi":"10.1101/cshperspect.a041660","DOIUrl":null,"url":null,"abstract":"Optogenetics has emerged over the past 20 years as a powerful tool to investigate the various circuits underlying numerous functions, especially in neuroscience. The ability to control by light the activity of neurons has enabled the development of therapeutic strategies aimed at restoring some level of vision in blinding retinal conditions. Promising preclinical and initial clinical data support such expectations. Numerous challenges remain to be tackled (e.g., confirmation of safety, cell and circuit specificity, patterns, intensity and mode of stimulation, rehabilitation programs) on the path toward useful vision restoration.","PeriodicalId":10452,"journal":{"name":"Cold Spring Harbor perspectives in medicine","volume":" ","pages":""},"PeriodicalIF":7.8000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293536/pdf/","citationCount":"0","resultStr":"{\"title\":\"Optogenetic Vision Restoration.\",\"authors\":\"Volker Busskamp, Botond Roska, Jose-Alain Sahel\",\"doi\":\"10.1101/cshperspect.a041660\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Optogenetics has emerged over the past 20 years as a powerful tool to investigate the various circuits underlying numerous functions, especially in neuroscience. The ability to control by light the activity of neurons has enabled the development of therapeutic strategies aimed at restoring some level of vision in blinding retinal conditions. Promising preclinical and initial clinical data support such expectations. Numerous challenges remain to be tackled (e.g., confirmation of safety, cell and circuit specificity, patterns, intensity and mode of stimulation, rehabilitation programs) on the path toward useful vision restoration.\",\"PeriodicalId\":10452,\"journal\":{\"name\":\"Cold Spring Harbor perspectives in medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":7.8000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293536/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cold Spring Harbor perspectives in medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1101/cshperspect.a041660\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cold Spring Harbor perspectives in medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1101/cshperspect.a041660","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

在过去的20年里，光遗传学已经成为研究许多功能背后的各种电路的有力工具，尤其是在神经科学中。通过光控制神经元活动的能力使治疗策略得以发展，旨在在失明的视网膜条件下恢复一定程度的视力。有希望的临床前和初步临床数据支持这种期望。在实现有用的视力恢复的道路上，仍有许多挑战需要解决（例如，安全性、细胞和电路特异性、刺激模式、强度和模式、康复计划的确认）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Optogenetic Vision Restoration.

Optogenetics has emerged over the past 20 years as a powerful tool to investigate the various circuits underlying numerous functions, especially in neuroscience. The ability to control by light the activity of neurons has enabled the development of therapeutic strategies aimed at restoring some level of vision in blinding retinal conditions. Promising preclinical and initial clinical data support such expectations. Numerous challenges remain to be tackled (e.g., confirmation of safety, cell and circuit specificity, patterns, intensity and mode of stimulation, rehabilitation programs) on the path toward useful vision restoration.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

14.30

自引率

1.90%

发文量

审稿时长

4-8 weeks

期刊介绍： Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.