肺健康与疾病的机感通道。

IF 4.2 2区 医学 Q1 PHYSIOLOGY
Nataliya Migulina, Brian Kelley, Emily Y Zhang, Christina M Pabelick, Y S Prakash, Elizabeth R Vogel
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引用次数: 0

摘要

肺是一个固有的机械敏感器官,在健康和疾病中,气道和薄壁组织的细胞在一生中都会经历一系列机械力,包括剪切、拉伸和压缩。在这方面,儿童和成人肺部疾病,如喘息和哮喘、支气管肺发育不良(BPD)、慢性阻塞性肺病(COPD)和肺纤维化(PF),都在不同程度上涉及支气管气道和/或薄壁组织机械特性的宏观和细胞变化。因此,了解肺部如何感知机械力,以及细胞和组织在正常发育和健康与疾病条件下的反应变得非常重要。人们越来越认识到,将机械力转化为细胞反应涉及许多通道,其中一些通道本身具有机械敏感性。这些通道触发机械转导途径,可能进一步介导细胞重塑、炎症和其他病理生理机制,以应对拉伸、僵硬和炎症级联反应。肺病理生理学中出现了两个特别重要的通道家族:以TRPV4成员为重点的瞬时受体电位香草类通道家族和最近发现的压电(PZ)通道。在这里,我们探讨了TRPV4和PZ通道在肺部健康和疾病状态中的作用,重点是这些机械敏感通道与其局部环境(包括免疫细胞、细胞外基质和细胞骨架元件)之间的相互作用。我们进一步讨论了未来研究的潜在领域,以更好地了解机械通道对肺部健康和疾病的影响。©2023美国生理学会。Compr Physiol 13:5157-51782023。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechanosensitive Channels in Lung Health and Disease.

The lung is an inherently mechanosensitive organ, where cells of the airway and parenchyma experience a range of mechanical forces throughout life including shear, stretch, and compression, in both health and disease. In this regard, pediatric and adult lung diseases such as wheezing and asthma, bronchopulmonary dysplasia (BPD), chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis (PF) all involve macroscopic and cellular changes to the mechanical properties of the bronchial airways and/or parenchyma to varying extents. Accordingly, understanding how mechanical forces are sensed in the lung, and the responses of cells and tissues in the context of normal development and health versus disease conditions becomes highly relevant. There is increasing recognition that transduction of mechanical forces into cellular responses involves a number of channels, some of which are inherently mechanosensitive. Such channels trigger mechanotransduction pathways that may further mediate cellular remodeling, inflammation, and other pathophysiologic mechanisms in response to stretch, stiffness, and inflammatory cascades. Two particularly important channel families have emerged in pulmonary pathophysiology: the transient receptor potential vanilloid family with focus on member TRPV4 and the recently identified Piezo (PZ) channels. Here, we explore current understanding of the contributions of TRPV4 and PZ channels in lung health and disease states, focusing on the interactions between these mechanosensitive channels and their local environment including immune cells, the extracellular matrix, and cellular cytoskeletal elements. We further discuss potential areas for future research to better understand the impact of mechanical channels on pulmonary health and disease. © 2023 American Physiological Society. Compr Physiol 13:5157-5178, 2023.

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来源期刊
CiteScore
10.50
自引率
0.00%
发文量
38
审稿时长
6-12 weeks
期刊介绍: Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.
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