当代抗逆转录病毒治疗时代的艾滋病毒耐药性:临床视角。

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Andrew Carr, Nicola E Mackie, Roger Paredes, Kiat Ruxrungtham
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引用次数: 0

摘要

当代抗逆转录病毒疗法(ART)方案对耐药性的发展具有很高的障碍。然而,对早期抗逆转录病毒药物的耐药性和对当代抗逆转录病毒疗法的罕见耐药性表明,仍然需要对艾滋病毒耐药性进行良好的临床管理。在这里,我们描述了HIV耐药性机制、HIV耐药性突变的相互作用以及对当代抗逆转录病毒疗法的耐药性模式。然后,我们就HIV耐药性的管理提供指导,包括如何限制耐药性的发展和管理因耐药性而复杂化的病毒学失败。为了补充这一点,提供了资源和治疗指南的链接,这些链接可以帮助解释HIV耐药性测试结果,并在临床上选择最佳的抗逆转录病毒疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HIV drug resistance in the era of contemporary antiretroviral therapy: A clinical perspective.

Contemporary antiretroviral therapy (ART) regimens have high barriers to the development of drug resistance. However, resistance to earlier antiretrovirals and uncommon cases of resistance to contemporary ART illustrate the continued need for good clinical management of HIV drug resistance. Here, we describe HIV drug-resistance mechanisms, the interaction of HIV drug-resistant mutations and the patterns of drug resistance to contemporary ART. We then provide guidance on the management of HIV drug resistance, including how to limit the development of resistance and manage virologic failure that is complicated by resistance. To complement this, links to resources and treatment guidelines are provided that can assist with the interpretation of HIV drug resistance test results and optimal ART selection in the clinic.

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来源期刊
Antiviral Therapy
Antiviral Therapy 医学-病毒学
CiteScore
2.60
自引率
8.30%
发文量
35
审稿时长
4-8 weeks
期刊介绍: Antiviral Therapy (an official publication of the International Society of Antiviral Research) is an international, peer-reviewed journal devoted to publishing articles on the clinical development and use of antiviral agents and vaccines, and the treatment of all viral diseases. Antiviral Therapy is one of the leading journals in virology and infectious diseases. The journal is comprehensive, and publishes articles concerning all clinical aspects of antiviral therapy. It features editorials, original research papers, specially commissioned review articles, letters and book reviews. The journal is aimed at physicians and specialists interested in clinical and basic research.
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