{"title":"氧气在支气管肺发育不良的发展和治疗中的作用。","authors":"J.X. Sotiropoulos , J.L. Oei","doi":"10.1016/j.semperi.2023.151814","DOIUrl":null,"url":null,"abstract":"<div><p>Oxygen (O<sub>2</sub><span><span>) is crucial for both the development and treatment of one of the most important consequences of prematurity: </span>bronchopulmonary dysplasia<span> (BPD). In fetal life, the hypoxic environment is important for alveolar development and maturation. After birth, O</span></span><sub>2</sub> becomes a double-edged sword. While O<sub>2</sub><span> is needed to prevent hypoxia<span><span>, it also causes oxidative stress leading to a plethora of morbidities, including </span>retinopathy and BPD. The advent of continuous O</span></span><sub>2</sub><span> monitoring with pulse oximeters has allowed clinicians to recognize the narrow therapeutic margins of oxygenation for the preterm infant, but more knowledge is needed to understand what these ranges are at different stages of the preterm infant's life, including at birth, in the neonatal intensive care unit and after hospital discharge. Future research, especially in innovative technologies such as automated O</span><sub>2</sub><span> control and remote oximetry, will improve the understanding and treatment of the O</span><sub>2</sub> needs of infants with BPD.</p></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of oxygen in the development and treatment of bronchopulmonary dysplasia\",\"authors\":\"J.X. Sotiropoulos , J.L. Oei\",\"doi\":\"10.1016/j.semperi.2023.151814\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Oxygen (O<sub>2</sub><span><span>) is crucial for both the development and treatment of one of the most important consequences of prematurity: </span>bronchopulmonary dysplasia<span> (BPD). In fetal life, the hypoxic environment is important for alveolar development and maturation. After birth, O</span></span><sub>2</sub> becomes a double-edged sword. While O<sub>2</sub><span> is needed to prevent hypoxia<span><span>, it also causes oxidative stress leading to a plethora of morbidities, including </span>retinopathy and BPD. The advent of continuous O</span></span><sub>2</sub><span> monitoring with pulse oximeters has allowed clinicians to recognize the narrow therapeutic margins of oxygenation for the preterm infant, but more knowledge is needed to understand what these ranges are at different stages of the preterm infant's life, including at birth, in the neonatal intensive care unit and after hospital discharge. Future research, especially in innovative technologies such as automated O</span><sub>2</sub><span> control and remote oximetry, will improve the understanding and treatment of the O</span><sub>2</sub> needs of infants with BPD.</p></div>\",\"PeriodicalId\":21761,\"journal\":{\"name\":\"Seminars in perinatology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in perinatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0146000523001179\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in perinatology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0146000523001179","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
The role of oxygen in the development and treatment of bronchopulmonary dysplasia
Oxygen (O2) is crucial for both the development and treatment of one of the most important consequences of prematurity: bronchopulmonary dysplasia (BPD). In fetal life, the hypoxic environment is important for alveolar development and maturation. After birth, O2 becomes a double-edged sword. While O2 is needed to prevent hypoxia, it also causes oxidative stress leading to a plethora of morbidities, including retinopathy and BPD. The advent of continuous O2 monitoring with pulse oximeters has allowed clinicians to recognize the narrow therapeutic margins of oxygenation for the preterm infant, but more knowledge is needed to understand what these ranges are at different stages of the preterm infant's life, including at birth, in the neonatal intensive care unit and after hospital discharge. Future research, especially in innovative technologies such as automated O2 control and remote oximetry, will improve the understanding and treatment of the O2 needs of infants with BPD.
期刊介绍:
The purpose of each issue of Seminars in Perinatology is to provide authoritative and comprehensive reviews of a single topic of interest to professionals who care for the mother, the fetus, and the newborn. The journal''s readership includes perinatologists, obstetricians, pediatricians, epidemiologists, students in these fields, and others. Each issue offers a comprehensive review of an individual topic, with emphasis on new developments that will have a direct impact on their practice.