肝细胞癌基因分类。

IF 2.6 4区医学 Q3 ONCOLOGY

Cancer journal Pub Date : 2023-09-01 DOI:10.1097/PPO.0000000000000682

Zurabi Lominadze, Mohammed Rifat Shaik, Dabin Choi, Duha Zaffar, Lopa Mishra, Kirti Shetty

{"title":"肝细胞癌基因分类。","authors":"Zurabi Lominadze, Mohammed Rifat Shaik, Dabin Choi, Duha Zaffar, Lopa Mishra, Kirti Shetty","doi":"10.1097/PPO.0000000000000682","DOIUrl":null,"url":null,"abstract":"Abstract: Hepatocellular carcinoma (HCC) represents a significant global burden, with management complicated by its heterogeneity, varying presentation, and relative resistance to therapy. Recent advances in the understanding of the genetic, molecular, and immunological underpinnings of HCC have allowed a detailed classification of these tumors, with resultant implications for diagnosis, prognostication, and selection of appropriate treatments. Through the correlation of genomic features with histopathology and clinical outcomes, we are moving toward a comprehensive and unifying framework to guide our diagnostic and therapeutic approach to HCC.","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"29 5","pages":"249-258"},"PeriodicalIF":2.6000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686192/pdf/","citationCount":"0","resultStr":"{\"title\":\"Hepatocellular Carcinoma Genetic Classification.\",\"authors\":\"Zurabi Lominadze, Mohammed Rifat Shaik, Dabin Choi, Duha Zaffar, Lopa Mishra, Kirti Shetty\",\"doi\":\"10.1097/PPO.0000000000000682\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract: Hepatocellular carcinoma (HCC) represents a significant global burden, with management complicated by its heterogeneity, varying presentation, and relative resistance to therapy. Recent advances in the understanding of the genetic, molecular, and immunological underpinnings of HCC have allowed a detailed classification of these tumors, with resultant implications for diagnosis, prognostication, and selection of appropriate treatments. Through the correlation of genomic features with histopathology and clinical outcomes, we are moving toward a comprehensive and unifying framework to guide our diagnostic and therapeutic approach to HCC.\",\"PeriodicalId\":9655,\"journal\":{\"name\":\"Cancer journal\",\"volume\":\"29 5\",\"pages\":\"249-258\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686192/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/PPO.0000000000000682\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/PPO.0000000000000682","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

摘要：肝细胞癌（HCC）是一种重要的全球性负担，其异质性、不同表现和相对耐药性使其治疗变得复杂。最近对HCC的遗传、分子和免疫基础的理解取得了进展，从而对这些肿瘤进行了详细的分类，从而对诊断、预测和选择适当的治疗方法产生了影响。通过基因组特征与组织病理学和临床结果的相关性，我们正在朝着一个全面统一的框架迈进，以指导我们对HCC的诊断和治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Hepatocellular Carcinoma Genetic Classification.

Abstract: Hepatocellular carcinoma (HCC) represents a significant global burden, with management complicated by its heterogeneity, varying presentation, and relative resistance to therapy. Recent advances in the understanding of the genetic, molecular, and immunological underpinnings of HCC have allowed a detailed classification of these tumors, with resultant implications for diagnosis, prognostication, and selection of appropriate treatments. Through the correlation of genomic features with histopathology and clinical outcomes, we are moving toward a comprehensive and unifying framework to guide our diagnostic and therapeutic approach to HCC.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cancer journal 医学-肿瘤学

CiteScore

3.90

自引率

0.00%

发文量

102

审稿时长

7.5 months

期刊介绍： The Cancer Journal: The Journal of Principles & Practice of Oncology provides an integrated view of modern oncology across all disciplines. The Journal publishes original research and reviews, and keeps readers current on content published in the book Cancer: Principles & Practice of Oncology.