妊娠期和妊娠期给予顺式-9、反式-11和反式-10、顺式-12共轭亚油酸的胃给药不会影响后代的卵泡禀赋。

IF 1.6 4区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Animal Reproduction Pub Date : 2023-09-18 eCollection Date: 2023-01-01 DOI:10.1590/1984-3143-AR2022-0124
Danielle Storino de Freitas, Guilherme Antonio de Gouvêa Lopes, Barbara Rodrigues Nascimento, Ana Paula Madureira, Paulo Henrique Almeida Campos-Junior
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引用次数: 0

摘要

胎儿编程表明,在胎儿发育期间,母体的刺激和营养可以对后代进行编程。共轭亚油酸(CLA)是亚油酸的一种异构体,已在多个方面进行了表征,但很少有研究表明其参与生殖和胎儿编程。本研究的目的是评估妊娠期和妊娠期补充CLA的雌性小鼠的F1、F2和F3后代的生物特征和生殖参数以及卵巢形态生理学。补充CLA的母亲的F1后代表现出稳定的体重增加,而F2后代没有表现出任何影响(分别为P=0.0187和P=0.0245)。在用CLA处理的动物中,在断奶后的第二个评估周,在两代中都观察到李指数的降低(分别为P=0.0100和P=0.0078)。经CLA处理的F2代动物的肛门生殖器指数(P=0.0114和P0.05)、卵泡数(P>0.05)和窦卵泡中卵母细胞脂质含量的综合密度(P>0.05)均有所增加,表明该补充剂可以安全使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

C<i>is</i>-9, <i>trans</i>-11 and <i>trans</i>-10, <i>cis</i>-12 conjugated linoleic acid gastric administration during the pregestational and gestational periods does not influence the follicular endowment of the progeny.

C<i>is</i>-9, <i>trans</i>-11 and <i>trans</i>-10, <i>cis</i>-12 conjugated linoleic acid gastric administration during the pregestational and gestational periods does not influence the follicular endowment of the progeny.

C<i>is</i>-9, <i>trans</i>-11 and <i>trans</i>-10, <i>cis</i>-12 conjugated linoleic acid gastric administration during the pregestational and gestational periods does not influence the follicular endowment of the progeny.

Cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid gastric administration during the pregestational and gestational periods does not influence the follicular endowment of the progeny.

Fetal programming suggests that maternal stimulation and nutrition during the period of fetal development can program the progeny. Conjugated linoleic acid (CLA), an isomer of linoleic acid, has been characterized in several aspects, but few studies have been performed on its involvement in reproduction and fetal programming. The aim of this study was to evaluate the F1, F2 and F3 progeny of female mice supplemented with CLA during the pregestational and gestational periods with respect to biometric and reproductive parameters, as well as ovarian morphophysiology. The F1 progeny of mothers supplemented with CLA exhibited stable weight gain, while the F2 progeny showed no effects (P=0.0187 and P=0.0245, respectively). A reduction in Lee's Index was observed in both generations at the second post-weaning evaluation week in the animals treated with CLA (P=0.0100 and P=0.0078, respectively). The F2 generation showed an increase in the anogenital index in both sexes of the animals treated with CLA (P= 0.0114 and P<0.0001, female and male respectively). CLA administration to mothers did not affect any of the following in their progeny: ovarian follicle mobilization (P>0.05), follicle number (P>0.05) and the integrated density of the lipid content of oocytes included in antral follicles (P>0.05). This study evaluated the use of CLA in mothers and found that it did not affect the progeny regarding murine reproductive performance, suggesting that this supplement can be used safely.

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来源期刊
Animal Reproduction
Animal Reproduction AGRICULTURE, DAIRY & ANIMAL SCIENCE-
CiteScore
2.30
自引率
11.80%
发文量
49
审稿时长
70 days
期刊介绍: Animal Reproduction (AR) publishes original scientific papers and invited literature reviews, in the form of Basic Research, Biotechnology, Applied Research and Review Articles, with the goal of contributing to a better understanding of phenomena related to animal reproduction. The scope of the journal applies to students, researchers and practitioners in the fields of veterinary, biology and animal science, also being of interest to practitioners of human medicine. Animal Reproduction Journal is the official organ of the Brazilian College of Animal Reproduction in Brazil.
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