糖脂三肽（N-乳糖醇-Gly）2-LysC16及其荧光标记类似物用于可视化将生物活性物质递送到靶细胞的载体系统

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY

Moscow University Chemistry Bulletin Pub Date : 2023-10-01 DOI:10.3103/S0027131423050036

K. A. Afanasyeva, A. M. Gileva, E. A. Markvicheva, U. A. Budanova, Y. L. Sebyakin

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引用次数: 0

摘要

本文研究了一种不规则结构的脂三肽（N-丙交酯-Gly）2-LysC16的碳水化合物衍生物的制备，该衍生物具有D-半乳糖的两个末端残基，这是一种基于脂族L-赖氨酸及其无碳水化合物类似物的支链，在疏水性片段中以1-芘丁醇为荧光标记。所开发的合成方案包括肽化学的通用方法和在两亲物的亲水结构域中形成基于乳糖的无环碳水化合物的阶段。这些化合物被设计用于产生载体BAS递送系统的组合物，该系统能够可视化与靶细胞的相互作用过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Glycolipotripeptide (N-Lactitol-Gly)2-LysC16 and Its Fluorescently Labeled Analog for Visualizing Vector Systems for the Delivery of Biologically Active Substances to Target Cells

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Glycolipotripeptide (N-Lactitol-Gly)2-LysC16 and Its Fluorescently Labeled Analog for Visualizing Vector Systems for the Delivery of Biologically Active Substances to Target Cells

This paper studies the preparation of a carbohydrate derivative of lipotripeptide (N-lactitol-Gly)₂-LysC₁₆ of an irregular structure with two terminal residues of D-galactose, a branching link based on aliphatic L-lysine and its carbohydrate-free analog with 1-pyrenbutanol as a fluorescent label in a hydrophobic fragment. The developed synthesis scheme includes universal approaches of peptide chemistry and the stages of the formation of an acyclic carbohydrate based on lactose in the hydrophilic domain of amphiphile. The compounds are designed to create compositions of the vector BAS delivery systems with the ability to visualize the process of interaction with the target cells.

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来源期刊

Moscow University Chemistry Bulletin CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.30

自引率

14.30%

发文量

期刊介绍： Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.