白念珠菌粗提物的镇痛作用。

Bollettino chimico farmaceutico Pub Date : 2003-10-01

M A Lemos Vasconcelos, D da Silva Ferreira, M L Andrade e Silva, R Cassio Sola Veneziani, W R Cunha

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引用次数: 0

摘要

采用扭体实验和热板模型研究了从白色Miconia albicans (Melastomataceae)地上部分提取的粗提物(己烷、二氯甲烷和乙醇)对小鼠疼痛的镇痛作用。口服己烷和二氯甲烷提取物，在扭体实验中有明显的抗伤作用。另一方面，没有一种提取物对热板试验有显著的影响，这一事实表明，提取物中存在的物质可能具有外周镇痛活性。

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Analgesic effects of crude extracts of Miconia albicans (Melastomataceae).

The present study describes the analgesic effects of the crude extracts (hexane, methylene chloride and ethanol) obtained from the aerial parts of Miconia albicans (Melastomataceae) using the writhing test and the hot plate models for pain in mice. The extracts in hexane and methylene chloride, given orally, produced significant antinociception in the writhing test. On the other hand, none of the extracts had a significant effect on the hot plate test, a fact suggesting that the substances present in the extracts may rather have peripheral analgesic activity.

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Bollettino chimico farmaceutico

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