锌(II)悬浮液中脉动性和持续性肽释放。

Bollettino chimico farmaceutico Pub Date : 2003-10-01
F Ryszka, B Dolinska
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引用次数: 0

摘要

在体外条件下,观察了锌(II)-肽配合物以50:1的摩尔比以固体形式从悬浮液中释放肽的动力学。与去甲肾上腺素的释放相比,混悬液中甲状腺素和达拉林的释放具有统计学意义。观察了达拉雷线、促性腺素和甲状腺素释放的6个显著峰的肽释放脉动特征。从所获得的混悬液中,甲状腺自由碱释放速度最快,为63 h +/- 3.1,而达拉雷线释放速度最慢,为26.5 h +/- 2.3。悬浮液中促性腺激素释放时间为12.0 h +/- 1.0。肽的分子量和锌(II)-肽配合物的性质对肽从悬浮液中释放的性质和时间有重要影响。锌(II)-肽络合物的分子量和持久性越大,悬浮液中释放的肽峰数越多。释放肽的分子量越大,释放时间越长。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pulsatile and sustained peptides release from Zn(II) suspensions.

The dynamics of peptide release from suspensions in the form of solid, sparingly soluble Zn(II)-Peptide complexes in molar ratio 50:1 was observed in vitro conditions. Thyroliberine and dalareline release from suspensions is statistically significant in comparison with gonadrenaline release. Pulsatile character of peptide release in 6 significant peaks of released dalareline, 5--of gonadoreline release and 4--thyroliberine were observed. Thyroliberine was released fastest from the obtained suspensions--63 h +/- 3.1, and dalareline was released slowest--26.5 h +/- 2.3. The release time for gonadoreline from suspensions was 12.0 h +/- 1.0. Molecular weight of the peptide and properties of the Zn(II)-Peptide complexes have major influence upon the character and time of peptide release from suspensions. The greater is the molecular weight and durability of Zn(II)-Peptide complex, the bigger is the number of peaks of the peptide released from suspensions. The release time of the peptides is longer when the molecular weight of the released peptide is bigger.

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