一系列手性1,4-二取代哌嗪衍生物在碳水化合物手性固定相上的结构-保留关系

Farmaco (Societa chimica italiana : 1989) Pub Date : 2005-05-01 DOI:10.1016/j.farmac.2005.01.006

Zdzisław Chilmonczyk , Łukasz Sienicki , Bożena Łozowicka , Małgorzata Lisowska-Kuźmicz , Anna Jończyk , Hassan Y. Aboul-Enein

{"title":"一系列手性1,4-二取代哌嗪衍生物在碳水化合物手性固定相上的结构-保留关系","authors":"Zdzisław Chilmonczyk , Łukasz Sienicki , Bożena Łozowicka , Małgorzata Lisowska-Kuźmicz , Anna Jończyk , Hassan Y. Aboul-Enein","doi":"10.1016/j.farmac.2005.01.006","DOIUrl":null,"url":null,"abstract":"<div>New racemic 1,4-disubstituted piperazines chemically named ethyl 2-[(4-pyrimidin-2yl-piperazine-1yl)carbonyl]C3-C5-alkanoates 1-7 were synthesized. The compounds were resolved into enantiomers on cellulose tris(4-methylbenzoate) and amylose tris(3,5-dimethylphenylcarbamate) stationary phases using hexane/propan-2-ol mobile phases. The optimum separation conditions for the compounds were obtained on cellulose tris(4-methylbenzoate) with 5% of 2-propanol in hexane. The relationship between structural and chromatographic parameters is discussed.</div>","PeriodicalId":77128,"journal":{"name":"Farmaco (Societa chimica italiana : 1989)","volume":"60 5","pages":"Pages 439-443"},"PeriodicalIF":0.0000,"publicationDate":"2005-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmac.2005.01.006","citationCount":"5","resultStr":"{\"title\":\"Structure–Retention Relationship in a Series of Chiral 1,4-Disubstituted Piperazine Derivatives on Carbohydrate Chiral Stationary Phases\",\"authors\":\"Zdzisław Chilmonczyk , Łukasz Sienicki , Bożena Łozowicka , Małgorzata Lisowska-Kuźmicz , Anna Jończyk , Hassan Y. Aboul-Enein\",\"doi\":\"10.1016/j.farmac.2005.01.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>New racemic 1,4-disubstituted piperazines chemically named ethyl 2-[(4-pyrimidin-2yl-piperazine-1yl)carbonyl]C3-C5-alkanoates 1-7 were synthesized. The compounds were resolved into enantiomers on cellulose tris(4-methylbenzoate) and amylose tris(3,5-dimethylphenylcarbamate) stationary phases using hexane/propan-2-ol mobile phases. The optimum separation conditions for the compounds were obtained on cellulose tris(4-methylbenzoate) with 5% of 2-propanol in hexane. The relationship between structural and chromatographic parameters is discussed.</div>\",\"PeriodicalId\":77128,\"journal\":{\"name\":\"Farmaco (Societa chimica italiana : 1989)\",\"volume\":\"60 5\",\"pages\":\"Pages 439-443\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.farmac.2005.01.006\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Farmaco (Societa chimica italiana : 1989)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0014827X05000285\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Farmaco (Societa chimica italiana : 1989)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014827X05000285","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 5

摘要

合成了新的外消旋1,4-二取代哌嗪，化学名称为乙基2-[(4-嘧啶-2基-哌嗪-1基)羰基]c3 - c5 -烷酸酯1-7。在纤维素三(4-甲基苯甲酸酯)和直链淀粉三(3,5-二甲基苯基氨基甲酸酯)固定相上用己烷/丙烷-2-醇流动相分离成对映体。在纤维素三(4-甲基苯甲酸酯)和5%的正己烷- 2-丙醇上得到了化合物的最佳分离条件。讨论了结构参数与色谱参数之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Structure–Retention Relationship in a Series of Chiral 1,4-Disubstituted Piperazine Derivatives on Carbohydrate Chiral Stationary Phases

New racemic 1,4-disubstituted piperazines chemically named ethyl 2-[(4-pyrimidin-2yl-piperazine-1yl)carbonyl]C3-C5-alkanoates 1-7 were synthesized. The compounds were resolved into enantiomers on cellulose tris(4-methylbenzoate) and amylose tris(3,5-dimethylphenylcarbamate) stationary phases using hexane/propan-2-ol mobile phases. The optimum separation conditions for the compounds were obtained on cellulose tris(4-methylbenzoate) with 5% of 2-propanol in hexane. The relationship between structural and chromatographic parameters is discussed.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Farmaco (Societa chimica italiana : 1989)

自引率

0.00%

发文量