{"title":"豚鼠抗胰岛素抗体的生物学特性。","authors":"J M CORCOS, Z OVARY","doi":"10.3181/00379727-119-30121","DOIUrl":null,"url":null,"abstract":"Summary 1. Precipitating antibodies to insulin have been demonstrated in the guinea pig. 2. Two types of 7S anti-insulin antibodies were separated by zone electrophoresis and were shown to have different biological activities. The slower moving gamma 2 antibodies provoked hemagglutination and hemolysis in presence of complement. The faster moving gamma 1 antibodies gave PCA reactions in the guinea pig. 3. Oxidized B chain of insulin did not share antigenic determinants with the intact insulin molecule.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"142-8"},"PeriodicalIF":0.0000,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30121","citationCount":"14","resultStr":"{\"title\":\"BIOLOGICAL PROPERTIES OF GUINEA PIG ANTI-INSULIN ANTIBODIES.\",\"authors\":\"J M CORCOS, Z OVARY\",\"doi\":\"10.3181/00379727-119-30121\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Summary 1. Precipitating antibodies to insulin have been demonstrated in the guinea pig. 2. Two types of 7S anti-insulin antibodies were separated by zone electrophoresis and were shown to have different biological activities. The slower moving gamma 2 antibodies provoked hemagglutination and hemolysis in presence of complement. The faster moving gamma 1 antibodies gave PCA reactions in the guinea pig. 3. Oxidized B chain of insulin did not share antigenic determinants with the intact insulin molecule.\",\"PeriodicalId\":20675,\"journal\":{\"name\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"142-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1965-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3181/00379727-119-30121\",\"citationCount\":\"14\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3181/00379727-119-30121\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Society for Experimental Biology and Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3181/00379727-119-30121","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
BIOLOGICAL PROPERTIES OF GUINEA PIG ANTI-INSULIN ANTIBODIES.
Summary 1. Precipitating antibodies to insulin have been demonstrated in the guinea pig. 2. Two types of 7S anti-insulin antibodies were separated by zone electrophoresis and were shown to have different biological activities. The slower moving gamma 2 antibodies provoked hemagglutination and hemolysis in presence of complement. The faster moving gamma 1 antibodies gave PCA reactions in the guinea pig. 3. Oxidized B chain of insulin did not share antigenic determinants with the intact insulin molecule.
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