{"title":"人“成纤维细胞”在体外形成的透明质酸固有粘度的调节:氢化可的松和秋水仙碱的作用","authors":"C. William Castor, Robert K. Prince","doi":"10.1016/0926-6526(64)90032-1","DOIUrl":null,"url":null,"abstract":"<div><p>Data are presented to show that the intrinsic viscosity of hyaluronic acid elaborated into the culture medium supportinf human connective-tissue cells <em>in vitro</em> is modulated in a systematic manner by the cells. Intrinsic viscosity is reduced during rapid cell division and by hydrocortisone treatment. Conversely, the initial lag phase of culture growth and colchicine treatment are attended by formation of hyaluronic acid with a high intrinsic viscosity.</p></div>","PeriodicalId":100172,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides","volume":"83 2","pages":"Pages 165-177"},"PeriodicalIF":0.0000,"publicationDate":"1964-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6526(64)90032-1","citationCount":"40","resultStr":"{\"title\":\"Modulation of the intrinsic viscosity of hyaluronic acid formed by human “fibroblasts” in vitro: The effects of hydrocortisone and colchicine\",\"authors\":\"C. William Castor, Robert K. Prince\",\"doi\":\"10.1016/0926-6526(64)90032-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Data are presented to show that the intrinsic viscosity of hyaluronic acid elaborated into the culture medium supportinf human connective-tissue cells <em>in vitro</em> is modulated in a systematic manner by the cells. Intrinsic viscosity is reduced during rapid cell division and by hydrocortisone treatment. Conversely, the initial lag phase of culture growth and colchicine treatment are attended by formation of hyaluronic acid with a high intrinsic viscosity.</p></div>\",\"PeriodicalId\":100172,\"journal\":{\"name\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides\",\"volume\":\"83 2\",\"pages\":\"Pages 165-177\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1964-07-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0926-6526(64)90032-1\",\"citationCount\":\"40\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0926652664900321\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0926652664900321","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Modulation of the intrinsic viscosity of hyaluronic acid formed by human “fibroblasts” in vitro: The effects of hydrocortisone and colchicine
Data are presented to show that the intrinsic viscosity of hyaluronic acid elaborated into the culture medium supportinf human connective-tissue cells in vitro is modulated in a systematic manner by the cells. Intrinsic viscosity is reduced during rapid cell division and by hydrocortisone treatment. Conversely, the initial lag phase of culture growth and colchicine treatment are attended by formation of hyaluronic acid with a high intrinsic viscosity.
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