{"title":"心脏瓣膜的生物化学研究2。衰老和抗炎药物对牛心脏瓣膜合成6-磷酸氨基葡萄糖和硫酸磷酸腺苷的影响","authors":"Bernard Jacobson , Harry Boström","doi":"10.1016/0926-6526(64)90031-X","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. <span>l</span>-Glutamine-<span>d</span>-fructose 6-phosphate aminotransferase (EC 2.6.1.16) has been isolated from liquid nitrogen-powdered aortic and pulmonary-valves of calves and cows.</p></span></li><li><span>2.</span><span><p>2. Young valves show greater enzymatic activity than older, while, in calves, the aortic-valve aminotransferase is more active than the pulmonary-valve enzyme.</p></span></li><li><span>3.</span><span><p>3. Sodium salicylate produces a marked inhibition of the aortic and pulmonary-valve aminotransferase, while its isomer, <em>p</em>-hydroxybenzoic acid has a much less inhibitory effect. Chloroquine diphosphate causes a marked inhibition only at high concentration.</p></span></li><li><span>4.</span><span><p>4. The aortic and pulmonary-valve 3′-phosphoadenosine-5′-phosphosulphate-synthesizing systems have been isolated and have been found to be unaffected by the drugs studied.</p></span></li><li><span>5.</span><span><p>5. The possibility of the enzymatic synthesis of glucosamine 6-phosphate being one control point for the action of some anti-inflammatory drugs is discussed.</p></span></li></ul></div>","PeriodicalId":100172,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides","volume":"83 2","pages":"Pages 152-164"},"PeriodicalIF":0.0000,"publicationDate":"1964-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6526(64)90031-X","citationCount":"15","resultStr":"{\"title\":\"Studies on the biochemistry of heart valves II. The effect of aging and anti-inflammatory drugs on the synthesis of glucosamine 6-phosphate and phosphoadenosine phosphosulfate by bovine heart valves\",\"authors\":\"Bernard Jacobson , Harry Boström\",\"doi\":\"10.1016/0926-6526(64)90031-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. <span>l</span>-Glutamine-<span>d</span>-fructose 6-phosphate aminotransferase (EC 2.6.1.16) has been isolated from liquid nitrogen-powdered aortic and pulmonary-valves of calves and cows.</p></span></li><li><span>2.</span><span><p>2. Young valves show greater enzymatic activity than older, while, in calves, the aortic-valve aminotransferase is more active than the pulmonary-valve enzyme.</p></span></li><li><span>3.</span><span><p>3. Sodium salicylate produces a marked inhibition of the aortic and pulmonary-valve aminotransferase, while its isomer, <em>p</em>-hydroxybenzoic acid has a much less inhibitory effect. Chloroquine diphosphate causes a marked inhibition only at high concentration.</p></span></li><li><span>4.</span><span><p>4. The aortic and pulmonary-valve 3′-phosphoadenosine-5′-phosphosulphate-synthesizing systems have been isolated and have been found to be unaffected by the drugs studied.</p></span></li><li><span>5.</span><span><p>5. The possibility of the enzymatic synthesis of glucosamine 6-phosphate being one control point for the action of some anti-inflammatory drugs is discussed.</p></span></li></ul></div>\",\"PeriodicalId\":100172,\"journal\":{\"name\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides\",\"volume\":\"83 2\",\"pages\":\"Pages 152-164\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1964-07-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0926-6526(64)90031-X\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/092665266490031X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/092665266490031X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Studies on the biochemistry of heart valves II. The effect of aging and anti-inflammatory drugs on the synthesis of glucosamine 6-phosphate and phosphoadenosine phosphosulfate by bovine heart valves
1.
1. l-Glutamine-d-fructose 6-phosphate aminotransferase (EC 2.6.1.16) has been isolated from liquid nitrogen-powdered aortic and pulmonary-valves of calves and cows.
2.
2. Young valves show greater enzymatic activity than older, while, in calves, the aortic-valve aminotransferase is more active than the pulmonary-valve enzyme.
3.
3. Sodium salicylate produces a marked inhibition of the aortic and pulmonary-valve aminotransferase, while its isomer, p-hydroxybenzoic acid has a much less inhibitory effect. Chloroquine diphosphate causes a marked inhibition only at high concentration.
4.
4. The aortic and pulmonary-valve 3′-phosphoadenosine-5′-phosphosulphate-synthesizing systems have been isolated and have been found to be unaffected by the drugs studied.
5.
5. The possibility of the enzymatic synthesis of glucosamine 6-phosphate being one control point for the action of some anti-inflammatory drugs is discussed.
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