一种改进的人胰岛素原c肽固相合成方法。

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica Pub Date : 2003-10-01

Jia-Hao Shi, Jiang Li, Cai-E Ju, Da-Fu Cui

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摘要

将谷氨酸的-羧基与MBHA树脂的氨基结合，采用固相法制备了含c端谷氨酰胺的人胰岛素原c肽。保护基团被HF切割。MBHA树脂相对便宜。该方法为制备人胰岛素原c肽提供了新的途径。本文还报道了用PAM树脂制备类似物的人胰岛素原c肽。

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[An improved solid phase synthesis of human proinsulin C-peptide].

Human proinsulin C-peptide with C-terminal glutamine amide could be prepared through solid phase method by combining the gamma-carboxyl group of glutamic acid with the amino group of MBHA resin. The protecting groups were cleaved by HF. MBHA resin is relatively inexpensive. The new method is another way for the preparation of human proinsulin C-peptide. The preparation human proinsulin C-peptide of analogue using of PAM resin was also reported.

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Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica

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