{"title":"吖啶部分对Cu(II)[1,4,7 -三氮杂环壬烷]与DNA结合及反应的影响。","authors":"Tomoya Hirohama, Makoto Chikira","doi":"10.1093/nass/3.1.91","DOIUrl":null,"url":null,"abstract":"<p><p>The orientation and the dynamic behavior of Cu(II) complex of 1,4,7-triazacyclononane ([9]aneN3) and its acridine conjugate on B-form DNA fiber have been investigated by EPR spectroscopy. It has been shown that a Cu([9]aneN3)2+ binds to DNA with two different binding modes at room temperature; one species is rapidly moving and the other is immobilized randomly on the DNA. An introduction of acridine to 1,4,7-triazacyclononane fixed the orientation of all the Cu(II) complex with the g// axis perpendicular to DNA fiber axis, indicating that the tetragonal coordination plane is almost parallel to the DNA double helical axis.</p>","PeriodicalId":86149,"journal":{"name":"Nucleic acids research. Supplement (2001)","volume":" 3","pages":"91-2"},"PeriodicalIF":0.0000,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/nass/3.1.91","citationCount":"0","resultStr":"{\"title\":\"The effect of acridine moiety for binding and reaction of Cu(II)[1 ,4,7-triazacyclononane] with DNA.\",\"authors\":\"Tomoya Hirohama, Makoto Chikira\",\"doi\":\"10.1093/nass/3.1.91\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The orientation and the dynamic behavior of Cu(II) complex of 1,4,7-triazacyclononane ([9]aneN3) and its acridine conjugate on B-form DNA fiber have been investigated by EPR spectroscopy. It has been shown that a Cu([9]aneN3)2+ binds to DNA with two different binding modes at room temperature; one species is rapidly moving and the other is immobilized randomly on the DNA. An introduction of acridine to 1,4,7-triazacyclononane fixed the orientation of all the Cu(II) complex with the g// axis perpendicular to DNA fiber axis, indicating that the tetragonal coordination plane is almost parallel to the DNA double helical axis.</p>\",\"PeriodicalId\":86149,\"journal\":{\"name\":\"Nucleic acids research. Supplement (2001)\",\"volume\":\" 3\",\"pages\":\"91-2\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2003-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1093/nass/3.1.91\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nucleic acids research. Supplement (2001)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/nass/3.1.91\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nucleic acids research. Supplement (2001)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/nass/3.1.91","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of acridine moiety for binding and reaction of Cu(II)[1 ,4,7-triazacyclononane] with DNA.
The orientation and the dynamic behavior of Cu(II) complex of 1,4,7-triazacyclononane ([9]aneN3) and its acridine conjugate on B-form DNA fiber have been investigated by EPR spectroscopy. It has been shown that a Cu([9]aneN3)2+ binds to DNA with two different binding modes at room temperature; one species is rapidly moving and the other is immobilized randomly on the DNA. An introduction of acridine to 1,4,7-triazacyclononane fixed the orientation of all the Cu(II) complex with the g// axis perpendicular to DNA fiber axis, indicating that the tetragonal coordination plane is almost parallel to the DNA double helical axis.
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