{"title":"乙乙醇或热对原发性斑疹伤寒与复发性斑疹伤寒19和7s补体固定抗体的分化作用。","authors":"E S MURRAY, J M O'CONNOR, J A GAON","doi":"10.3181/00379727-119-30161","DOIUrl":null,"url":null,"abstract":"Summary The CF test can be modified so as to permit the differentiation of 19S and 7S antibodies in primary and secondary typhus infections. The 19S CF antibodies are markedly inhibited by the sulfhydryl compound ethanethiol and to a lesser degree by 60° C inactivation of the sera, The 7S CF antibodies are not inhibited by either of these procedures. The technic described may have application to the clinical and epidemiological investigation of other infectious diseases and may prove useful as a tool in studies of the immune globulins.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"291-7"},"PeriodicalIF":0.0000,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30161","citationCount":"28","resultStr":"{\"title\":\"DIFFERENTIATION OF 19S AND 7S COMPLEMENT FIXING ANTIBODIES IN PRIMARY VERSUS RECRUDESCENT TYPHUS BY EITHER ETHANETHIOL OR HEAT.\",\"authors\":\"E S MURRAY, J M O'CONNOR, J A GAON\",\"doi\":\"10.3181/00379727-119-30161\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Summary The CF test can be modified so as to permit the differentiation of 19S and 7S antibodies in primary and secondary typhus infections. The 19S CF antibodies are markedly inhibited by the sulfhydryl compound ethanethiol and to a lesser degree by 60° C inactivation of the sera, The 7S CF antibodies are not inhibited by either of these procedures. The technic described may have application to the clinical and epidemiological investigation of other infectious diseases and may prove useful as a tool in studies of the immune globulins.\",\"PeriodicalId\":20675,\"journal\":{\"name\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"291-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1965-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3181/00379727-119-30161\",\"citationCount\":\"28\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3181/00379727-119-30161\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Society for Experimental Biology and Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3181/00379727-119-30161","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
DIFFERENTIATION OF 19S AND 7S COMPLEMENT FIXING ANTIBODIES IN PRIMARY VERSUS RECRUDESCENT TYPHUS BY EITHER ETHANETHIOL OR HEAT.
Summary The CF test can be modified so as to permit the differentiation of 19S and 7S antibodies in primary and secondary typhus infections. The 19S CF antibodies are markedly inhibited by the sulfhydryl compound ethanethiol and to a lesser degree by 60° C inactivation of the sera, The 7S CF antibodies are not inhibited by either of these procedures. The technic described may have application to the clinical and epidemiological investigation of other infectious diseases and may prove useful as a tool in studies of the immune globulins.
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