{"title":"加压素合成类似物对血管平滑肌的影响。","authors":"B M ALTURA, S G HERSHEY, B W ZWEIFACH","doi":"10.3181/00379727-119-30152","DOIUrl":null,"url":null,"abstract":"Summary PLV-2, a synthetic analogue of vasopressin, applied topically to the micro-vessels in the rat mesoappendix produces a graded dose response reduction in true capillary blood flow. The various vessel types contract from the venular to the arteriolar loops; the opposite of their normal profile of reactivity. This polypeptide, when injected i.v. in a single dose potentiates constrictor responses to topically applied catecholamines. In contrast to these microcirculatory effects, PLV-2 inhibits norepinephrine-induced contractions in the isolated rabbit aortic strip.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"258-61"},"PeriodicalIF":0.0000,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30152","citationCount":"39","resultStr":"{\"title\":\"EFFECTS OF A SYNTHETIC ANALOGUE OF VASOPRESSIN ON VASCULAR SMOOTH MUSCLE.\",\"authors\":\"B M ALTURA, S G HERSHEY, B W ZWEIFACH\",\"doi\":\"10.3181/00379727-119-30152\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Summary PLV-2, a synthetic analogue of vasopressin, applied topically to the micro-vessels in the rat mesoappendix produces a graded dose response reduction in true capillary blood flow. The various vessel types contract from the venular to the arteriolar loops; the opposite of their normal profile of reactivity. This polypeptide, when injected i.v. in a single dose potentiates constrictor responses to topically applied catecholamines. In contrast to these microcirculatory effects, PLV-2 inhibits norepinephrine-induced contractions in the isolated rabbit aortic strip.\",\"PeriodicalId\":20675,\"journal\":{\"name\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"258-61\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1965-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3181/00379727-119-30152\",\"citationCount\":\"39\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3181/00379727-119-30152\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Society for Experimental Biology and Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3181/00379727-119-30152","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
EFFECTS OF A SYNTHETIC ANALOGUE OF VASOPRESSIN ON VASCULAR SMOOTH MUSCLE.
Summary PLV-2, a synthetic analogue of vasopressin, applied topically to the micro-vessels in the rat mesoappendix produces a graded dose response reduction in true capillary blood flow. The various vessel types contract from the venular to the arteriolar loops; the opposite of their normal profile of reactivity. This polypeptide, when injected i.v. in a single dose potentiates constrictor responses to topically applied catecholamines. In contrast to these microcirculatory effects, PLV-2 inhibits norepinephrine-induced contractions in the isolated rabbit aortic strip.
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