{"title":"一些单羟基硬脂酸在完整大鼠体内的代谢","authors":"John Elovson","doi":"10.1016/0926-6542(64)90056-3","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. The rapid incorporation of label from intravenously administered serum-bound 9(10)-mono- and 12-monohydroxystearic acids into palmitic, stearic and octadecenoic acids in the intact rat has been demonstrated.</p></span></li><li><span>2.</span><span><p>2. Analysis of label distribution in the newly formed non-hydroxy acids, following different labeling of the injected monohydroxystearic acids, indicates that breakdown to, and resynthesis from, acetate accounted for this conversion.</p></span></li><li><span>3.</span><span><p>3. No evidence was found for a specific dehydration of monohydroxystearic acids to the unsaturated analogs.</p></span></li><li><span>4.</span><span><p>4. The monohydroxystearic acids were extremely rapidly broken down: less than one-fifth could be recovered as such from the whole rat 5 min after intravenous injection.</p></span></li></ul></div>","PeriodicalId":100171,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects","volume":"84 3","pages":"Pages 275-293"},"PeriodicalIF":0.0000,"publicationDate":"1964-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6542(64)90056-3","citationCount":"31","resultStr":"{\"title\":\"Metabolism of some monohydroxystearic acids in the intact rat\",\"authors\":\"John Elovson\",\"doi\":\"10.1016/0926-6542(64)90056-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. The rapid incorporation of label from intravenously administered serum-bound 9(10)-mono- and 12-monohydroxystearic acids into palmitic, stearic and octadecenoic acids in the intact rat has been demonstrated.</p></span></li><li><span>2.</span><span><p>2. Analysis of label distribution in the newly formed non-hydroxy acids, following different labeling of the injected monohydroxystearic acids, indicates that breakdown to, and resynthesis from, acetate accounted for this conversion.</p></span></li><li><span>3.</span><span><p>3. No evidence was found for a specific dehydration of monohydroxystearic acids to the unsaturated analogs.</p></span></li><li><span>4.</span><span><p>4. The monohydroxystearic acids were extremely rapidly broken down: less than one-fifth could be recovered as such from the whole rat 5 min after intravenous injection.</p></span></li></ul></div>\",\"PeriodicalId\":100171,\"journal\":{\"name\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects\",\"volume\":\"84 3\",\"pages\":\"Pages 275-293\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1964-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0926-6542(64)90056-3\",\"citationCount\":\"31\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0926654264900563\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0926654264900563","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Metabolism of some monohydroxystearic acids in the intact rat
1.
1. The rapid incorporation of label from intravenously administered serum-bound 9(10)-mono- and 12-monohydroxystearic acids into palmitic, stearic and octadecenoic acids in the intact rat has been demonstrated.
2.
2. Analysis of label distribution in the newly formed non-hydroxy acids, following different labeling of the injected monohydroxystearic acids, indicates that breakdown to, and resynthesis from, acetate accounted for this conversion.
3.
3. No evidence was found for a specific dehydration of monohydroxystearic acids to the unsaturated analogs.
4.
4. The monohydroxystearic acids were extremely rapidly broken down: less than one-fifth could be recovered as such from the whole rat 5 min after intravenous injection.
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