大麻素 CB1 和 CB2 受体在调节精神兴奋剂反应中的作用。

IF 3.8 4区医学 Q1 Medicine

Acta Neuropsychiatrica Pub Date : 2024-04-01 Epub Date: 2022-08-22 DOI:10.1017/neu.2022.23

P H Gobira, S R Joca, F A Moreira

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引用次数: 0

摘要

对可卡因、D-苯丙胺和甲基苯丙胺等精神兴奋剂药物上瘾是一个公共卫生问题，严重加重了全球的疾病负担。精神刺激类药物会促进皮质中层imbic 系统内多巴胺水平的升高，而多巴胺是此类药物奖励特性的核心。大麻素受体（CB1R 和 CB2R）在该系统的主要区域均有表达，并与精神兴奋药物奖励效应的神经元机制有关。在此，我们回顾了针对大麻素 CB1R 和 CB2R 的药理干预及其在调节精神兴奋剂反应中的相互作用的研究。

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Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses.

Addiction to psychostimulant drugs, such as cocaine, D-amphetamine, and methamphetamine, is a public health issue that substantially contributes to the global burden of disease. Psychostimulant drugs promote an increase in dopamine levels within the mesocorticolimbic system, which is central to the rewarding properties of such drugs. Cannabinoid receptors (CB₁R and CB₂R) are expressed in the main areas of this system and implicated in the neuronal mechanisms underlying the rewarding effect of psychostimulant drugs. Here, we reviewed studies focusing on pharmacological intervention targeting cannabinoid CB₁R and CB₂R and their interaction in the modulation of psychostimulant responses.

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来源期刊

Acta Neuropsychiatrica 医学-精神病学

CiteScore

8.50

自引率

5.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.