NEK2, TP53突变癌症的一个有希望的靶点。

IF 1.5 Q3 HEMATOLOGY
血液科学(英文) Pub Date : 2022-05-17 eCollection Date: 2022-04-01 DOI:10.1097/BS9.0000000000000106
Martina Cusan, Lili Wang
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引用次数: 1

摘要

本文章由计算机程序翻译,如有差异,请以英文原文为准。

NEK2, a promising target in TP53 mutant cancer.

NEK2, a promising target in TP53 mutant cancer.
In human cancers, aberration of tumor suppressors and oncogenes cooperate to contribute to tumor initiation and progression.TP53, one of the best-known tumor suppressors, appears to have diverse roles through working together with different oncogenes. A good example is RAS mutations cooccurringwithTP53 lesions.KRAS hyper-activation leads to cell replicative senescence, which could be overcome by lesions in TP53, escaping immune clearance surveillance and promoting
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CiteScore
1.70
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0.00%
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