{"title":"NEK2, TP53突变癌症的一个有希望的靶点。","authors":"Martina Cusan, Lili Wang","doi":"10.1097/BS9.0000000000000106","DOIUrl":null,"url":null,"abstract":"In human cancers, aberration of tumor suppressors and oncogenes cooperate to contribute to tumor initiation and progression.TP53, one of the best-known tumor suppressors, appears to have diverse roles through working together with different oncogenes. A good example is RAS mutations cooccurringwithTP53 lesions.KRAS hyper-activation leads to cell replicative senescence, which could be overcome by lesions in TP53, escaping immune clearance surveillance and promoting","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/41/bls-4-97.PMC9362867.pdf","citationCount":"1","resultStr":"{\"title\":\"NEK2, a promising target in TP53 mutant cancer.\",\"authors\":\"Martina Cusan, Lili Wang\",\"doi\":\"10.1097/BS9.0000000000000106\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In human cancers, aberration of tumor suppressors and oncogenes cooperate to contribute to tumor initiation and progression.TP53, one of the best-known tumor suppressors, appears to have diverse roles through working together with different oncogenes. A good example is RAS mutations cooccurringwithTP53 lesions.KRAS hyper-activation leads to cell replicative senescence, which could be overcome by lesions in TP53, escaping immune clearance surveillance and promoting\",\"PeriodicalId\":67343,\"journal\":{\"name\":\"血液科学(英文)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2022-05-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/41/bls-4-97.PMC9362867.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"血液科学(英文)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/BS9.0000000000000106\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/4/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"血液科学(英文)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/BS9.0000000000000106","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/4/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
In human cancers, aberration of tumor suppressors and oncogenes cooperate to contribute to tumor initiation and progression.TP53, one of the best-known tumor suppressors, appears to have diverse roles through working together with different oncogenes. A good example is RAS mutations cooccurringwithTP53 lesions.KRAS hyper-activation leads to cell replicative senescence, which could be overcome by lesions in TP53, escaping immune clearance surveillance and promoting
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