MiR-491在人类癌症中的抑瘤作用和机制

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

DNA and cell biology Pub Date : 2022-09-01 Epub Date: 2022-08-01 DOI:10.1089/dna.2022.0274

Farzad Sadri, Seyede Fatemeh Hosseini, Atena Aghayei, Mohammad Fereidouni, Zohreh Rezaei

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引用次数: 2

摘要

MicroRNAs (miRNAs)是一种短的非编码rna，它结合到靶mrna的3'非翻译区(3' UTR)上，在转录后控制基因表达。最近的适应症强调了它们在各种病理生理条件以及人类恶性肿瘤中的重要作用。失调的mirna在多种癌症中作为肿瘤抑制基因或致癌基因。MiR-491已被证明通过结合特定基因和信号级联反应对多种恶性肿瘤的肿瘤发生具有重要作用，从而阻止癌症进展。本文综述了miR-491在肿瘤细胞的调控机制和生物学过程中的表达，以及miR-491在各类人类癌症中的潜在治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The Tumor Suppressor Roles and Mechanisms of MiR-491 in Human Cancers.

MicroRNAs (miRNAs) are short non-coding RNAs that bind to the 3' untranslated region (3'' UTR) of target mRNAs to control gene expression post-transcriptionally. Recent indications have highlighted their important roles in a variety of pathophysiological conditions as well as human malignancies. Dysregulated miRNAs act as tumor suppressor genes or oncogenes in a variety of cancers. MiR-491 has been shown to have a major effect on tumorigenesis in multiple malignancies through binding to specific genes and signaling cascades, thereby preventing cancer progression. This review provides an overview of miR-491 expression in regulatory mechanisms and biological procedures of tumor cells, as well as the prospective possible treatment effects of various types of human cancers.

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来源期刊

DNA and cell biology 生物-生化与分子生物学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1.5 months

期刊介绍： DNA and Cell Biology delivers authoritative, peer-reviewed research on all aspects of molecular and cellular biology, with a unique focus on combining mechanistic and clinical studies to drive the field forward. DNA and Cell Biology coverage includes: Gene Structure, Function, and Regulation Gene regulation Molecular mechanisms of cell activation Mechanisms of transcriptional, translational, or epigenetic control of gene expression Molecular Medicine Molecular pathogenesis Genetic approaches to cancer and autoimmune diseases Translational studies in cell and molecular biology Cellular Organelles Autophagy Apoptosis P bodies Peroxisosomes Protein Biosynthesis and Degradation Regulation of protein synthesis Post-translational modifications Control of degradation Cell-Autonomous Inflammation and Host Cell Response to Infection Responses to cytokines and other physiological mediators Evasive pathways of pathogens.