肢端肥大症相关的回转性垂直皮肤

IF 1.6 4区 医学 Q4 CELL BIOLOGY
João Roque, Pedro Marques
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引用次数: 1

摘要

肢端肥大症是一种由生长激素(GH)分泌过多引起的疾病,导致胰岛素样生长因子1 (IGF-1)水平过高,几乎总是由垂体肿瘤引起。它通常与肢端增大、突出的面部特征和软组织过度生长有关。皮肤表现包括多毛、痤疮、皮赘、油性皮肤和黑棘皮病。然而,其他不常见的皮肤病特征,如回转性皮肤(CVG),也可能发生。在这里,我们回顾了肢端肥大相关的CVG,旨在提高人们对其可能发生的认识,并讨论了其病理生理、表现、治疗和鉴别诊断。我们对CVG,特别是与肢端肥大症相关的CVG进行了全面的文献检索。病例报告、原始研究和综述论文均被考虑在内。结果scvg是一种罕见的良性皮肤病变,其特征是头皮增厚和折叠,类似于脑回和脑沟。CVG的诊断主要依靠临床检查,但在病因不明的情况下可能需要组织活检。在肢端肥大症中,CVG似乎是由生长激素和IGF-1对皮肤和软组织的营养作用驱动的。虽然CVG在肢端肥大症中并不常见,但它似乎在男性患者中更常见。肢端肥大症相关CVG的治疗主要依赖于控制血清GH和IGF-1水平。在肢端肥大症得到最好的控制后,皮肤外科手术应保留给有严重审美困扰的患者。结论scvg是肢端肥大症的一种罕见表现,可能允许早期诊断和更快的治疗这些患者,反过来可能改善或完全逆转这种显著的皮肤病变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acromegaly-related cutis verticis gyrata

Objective

Acromegaly is a disorder caused by hypersecretion of growth hormone (GH), resulting in excessive levels of insulin-like growth factor 1 (IGF-1), and almost always due to a pituitary tumor. It is classically associated with acral enlargement, prominent facial features and soft tissue overgrowth. Skin manifestations include hirsutism, acne, skin tags, oily skin and acanthosis nigricans. However, other uncommon dermatological features, such as cutis verticis gyrata (CVG), may also occur. Here, we review acromegaly-related CVG aiming to raise awareness for its possible occurrence in this setting, and we discuss its pathophysiology, presentation, management and differential diagnosis.

Design

A comprehensive literature search regarding CVG, particularly CVG related to acromegaly, has been carried out. Case reports, original studies and review papers, were considered.

Results

CVG is a rare benign skin lesion characterized by thickened and folded scalp, resembling the brain gyri and sulci. The diagnosis of CVG mainly relies on clinical examination, although tissue biopsy may be necessary in case of uncertain etiology. In acromegaly, CVG appears to be driven by the trophic effects of GH and IGF-1 on skin and soft tissues. While CVG is uncommon in acromegaly, it seems to occur more frequently in male patients. The management of acromegaly-related CVG essentially relies on controlling the serum levels of GH and IGF-1. Surgical skin procedures should be reserved for patients with severe aesthetic distress, after achieving the best possible control of acromegaly.

Conclusions

CVG is a rare manifestation of acromegaly that may allow an earlier diagnosis and a swifter treatment of these patients, which in turn may improve or entirely reverse such remarkable skin lesions.

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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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